miR-193 expression differentiates telocytes from other stromal cells

被引：111

作者：

Cismasiu, V. B. ^{[1
,2
]}

Radu, E. ^{[2
]}

Popescu, L. M. ^{[1
,2
]}

机构：

[1] Victor Babes Natl Inst Pathol, Dept Adv Studies & Pico & Nanotechnol, Bucharest 050096, Romania

[2] Carol Davila Univ Med & Pharm, Dept Cellular & Mol Med, Bucharest, Romania

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2011年 / 15卷 / 05期

关键词：

telocytes; telopodes; microRNA; laser capture microdissection; MICRORNAS; CARDIOMYOCYTE; EPICARDIUM; ICLC;

D O I：

10.1111/j.1582-4934.2011.01325.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Telocytes (TCs) are a particular type of interstitial (stromal) cells defined by very long, moniliform telopodes. Their tissue location, between blood vessels and other cells such as cardiomyocytes (CMC) and neurons, suggests a role in intercellular signalling. In order to define a microRNA (miR) signature in cardiac TCs, we have found that miR-193 is differentially expressed between TCs and other interstitial cells. Because miR-193 regulates c-kit, our data support the previous finding that TCs express c-kit in certain circumstances. In addition, the miRs which are specific to CMC and other muscle cells (e.g. miR-133a, miR-208a) are absent in TCs. Overall the data reinforce the view that TCs are a particular type of interstitial (mesenchymal) cells.

引用

页码：1071 / 1074

页数：4

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