Understanding Age-Related Changes in Skeletal Muscle Metabolism: Differences Between Females and Males

被引：70

作者：

Gheller, Brandon J. F. ^{[1
]}

Riddle, Emily S. ^{[1
]}

Lem, Melinda R. ^{[1
]}

Thalacker-Mercer, Anna E. ^{[1
]}

机构：

[1] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA

来源：

ANNUAL REVIEW OF NUTRITION, VOL 36 | 2016年 / 36卷

关键词：

skeletal muscle; macronutrient; metabolism; aging; sex; HYDROXY-BETA-METHYLBUTYRATE; NECROSIS-FACTOR-ALPHA; MITOCHONDRIAL PROTEIN-SYNTHESIS; LIPOPROTEIN-LIPASE ACTIVITY; POLYCYSTIC-OVARY-SYNDROME; BODY-COMPOSITION CHANGES; ESSENTIAL AMINO-ACIDS; SEX STEROID-HORMONES; OLDER-ADULTS; INSULIN-RESISTANCE;

D O I：

10.1146/annurev-nutr-071715-050901

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Skeletal muscle is the largest metabolic organ system in the human body. As such, metabolic dysfunction occurring in skeletal muscle impacts whole-body nutrient homeostasis. Macronutrient metabolism changes within the skeletal muscle with aging, and these changes are associated in part with age-related skeletal muscle remodeling. Moreover, age-related changes in skeletal muscle metabolism are affected differentially between males and females and are likely driven by changes in sex hormones. Intrinsic and extrinsic factors impact observed age-related changes and sex-related differences in skeletal muscle metabolism. Despite some support for sex-specific differences in skeletal muscle metabolism with aging, more research is necessary to identify underlying differences in mechanisms. Understanding sex-specific aging skeletal muscle will assist with the development of therapies to attenuate adverse metabolic and functional outcomes.

引用

页码：129 / 156

页数：28

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