Hypogonadotropic hypogonadism in men with hereditary hemochromatosis

被引：17

作者：

El Osta, Rabih ^{[1
]}

Grandpre, Nicolas ^{[2
]}

Monnin, Nicolas ^{[3
]}

Hubert, Jacques ^{[1
]}

Koscinski, Isabelle ^{[3
]}

机构：

[1] CHU Nancy, Brabois Univ Hosp, Urol Dept, Vandoeuvre Les Nancy, France

[2] CHRU Strasbourg, Hematol Dept, Strasbourg, France

[3] CHU Nancy, CECOS Lorraine, Lab Biol Reprod, Nancy, France

来源：

BASIC AND CLINICAL ANDROLOGY | 2017年 / 27卷

关键词：

Male infertility; Hypogonadotropic Hypogonadism; Hereditary Hemochromatosis; PITUITARY-FUNCTION; IDIOPATHIC HEMOCHROMATOSIS; IRON; INFERTILITY; VENESECTION; HEPCIDIN; PATIENT; DAMAGE;

D O I：

10.1186/s12610-017-0057-8

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Hereditary hemochromatosis is a genetic disease that progresses silently. This disease is often diagnosed late when complications appear. Hypogonadotropic hypogonadism (HH) is one of the classical complications of hemochromatosis. Its frequency is declining probably because of earlier diagnosis and better informed physicians. Certain symptoms linked to HH can have an impact on a patient's sexuality, such as decreased libido, erectile dysfunction, and impairment of ejaculation, as well as on his reproductive capacities. This review is based on an online search in English, French and German language publications found in PubMed/Medline, up to 23 September 2016 using the following key word: Male infertility, Hypogonadotropic Hypogonadism, Hereditary Hemochromatosis. Thirty-four papers met these inclusion criteria. This review describes the impact of iron overload on male fertility, resulting in hypogonadotropic hypogonadism and proposes treatment modalities.

引用

页数：7

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