Mathematical modelling of ethanol production from glucose/xylose mixtures by recombinant Zymomonas mobilis

被引：70

作者：

Leksawasdi, N ^{[1
]}

Joachimsthal, EL ^{[1
]}

Rogers, PL ^{[1
]}

机构：

[1] Univ New S Wales, Dept Biotechnol, Sydney, NSW 2052, Australia

来源：

BIOTECHNOLOGY LETTERS | 2001年 / 23卷 / 13期

关键词：

ethanol; modelling; recombinant Zymomonas mobilis;

D O I：

10.1023/A:1010599530577

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A model has been developed for the fermentation of mixtures of glucose and xylose by recombinant Zymomonas mobilis strain ZM4(pZB5), containing additional genes for xylose assimilation and metabolism. A two-substrate model based on substrate limitation, substrate inhibition, and product (ethanol) inhibition was evaluated, and experimental data was compared with model simulations using a Microsoft EXCEL based program and methods of statistical analysis for error minimization. From the results it was established that the model provides good predictions of experimental batch culture data for 25/25, 50/50, and 65/65 g l(-1) glucose/xylose media.

引用

页码：1087 / 1093

页数：7

共 28 条

[1]

[Anonymous], 1941, RECHERCHES CROISSANC

[2]

[Anonymous], 1988, Nonlinear regression analysis and its applications

[3] D-GLUCOSE TRANSPORT-SYSTEM OF ZYMOMONAS-MOBILIS [J].

DIMARCO, AA ;

ROMANO, AH .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1985, 49 (01) :151-157

[4]

Draper NR., 1981, APPLIED REGRESSION A, P458

[5] Cybernetic model for the growth of Saccharomyces cerevisiae on melibiose [J].

Gadgil, CJ ;

Bhat, PJ ;

Venkatesh, KV .

BIOTECHNOLOGY PROGRESS, 1996, 12 (06) :744-750

[6] MATHEMATICAL-MODELING OF THE ALCOHOLIC FERMENTATION OF GLUCOSE BY ZYMOMONAS-MOBILIS MOBILIS [J].

GARRO, OA ;

RODRIGUEZ, E ;

UNDA, RP ;

CALLIERI, DAS .

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 1995, 63 (04) :367-373

[7]

HO NWY, 1996, 18 S BIOT FUELS CHEM

[8] Evaluation of recombinant strains of Zymomonas mobilis for ethanol production from glucose xylose media [J].

Joachimsthal, E ;

Haggett, KD ;

Rogers, PL .

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 1999, 77-9 (1-3) :147-157

[9] Characterization of a high-productivity recombinant strain of Zymomonas mobilis for ethanol production from glucose/xylose mixtures [J].

Joachimsthal, EL ;

Rogers, PL .

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2000, 84-6 (1-9) :343-356

[10] Ethanol production from glucose and xylose by immobilized Zymomonas mobilis CP4(pZB5) [J].

Krishnan, MS ;

Blanco, M ;

Shattuck, CK ;

Nghiem, NP ;

Davison, BH .

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2000, 84-6 (1-9) :525-541

← 1 2 3 →