Chinese expert recommendation on transnasal corticosteroid nebulization for the treatment of chronic rhinosinusitis 2021

被引：1

作者：

Wang, Chengshuo ^{[1
,2
,3
,4
]}

Cheng, Lei ^{[5
,6
,7
]}

Li, Huabin ^{[8
]}

Liu, Zheng ^{[9
]}

Lou, Hongfei ^{[1
,2
,3
,4
]}

Shi, Jianbo ^{[10
]}

Sun, Ying ^{[1
,2
,3
,11
]}

Wang, Dehui ^{[8
]}

Yang, Qintai ^{[12
]}

Yu, Hongmeng ^{[8
,13
]}

Zhao, Changqing ^{[14
]}

Zhu, Dongdong ^{[15
]}

Cheng, Fengli ^{[14
]}

Li, Yan ^{[1
,2
,3
,4
]}

Liao, Bo ^{[9
]}

Lu, Meiping ^{[5
,6
]}

Meng, Cuida ^{[15
]}

Shen, Shen ^{[1
,2
,3
,4
]}

Sun, Yueqi ^{[16
]}

Zheng, Rui ^{[12
]}

Zhang, Luo ^{[1
,2
,3
,4
,17
]}

机构：

[1] Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China

[2] Beijing Inst Otolaryngol, Beijing Lab Allerg Dis, Beijing, Peoples R China

[3] Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China

[4] Chinese Acad Med Sci, Res Unit Diag & Treatment Chron Nasal Dis, Beijing, Peoples R China

[5] Nanjing Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Nanjing, Peoples R China

[6] Nanjing Med Univ, Affiliated Hosp 1, Clin Allergy Ctr, Nanjing, Peoples R China

[7] Nanjing Med Univ, Int Ctr Allergy Res, Nanjing, Peoples R China

[8] Fudan Univ, Dept Otolaryngol Head Neck Surg, Eye & ENT Hosp, Shanghai, Peoples R China

[9] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Otolaryngol Head & Neck Surg, Wuhan, Peoples R China

[10] Sun Yat Sen Univ, Otorhinolaryngol Hosp, Affiliated Hosp 1, Guangzhou, Peoples R China

[11] Capital Med Univ, Sch Basic Med Sci, Dept Immunol, Beijing, Peoples R China

[12] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Otorhinolaryngol Head & Neck Surg, Dept Allergy, Guangzhou, Peoples R China

[13] Chinese Acad Med Sci, Res Units New Technol Endoscop Surg Skull Base Tu, Shanghai, Peoples R China

[14] Shanxi Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Hosp 2, Taiyuan, Peoples R China

[15] Jilin Univ, Dept Otorhinolaryngol Head & Neck Surg, China Japan Union Hosp, Changchun, Peoples R China

[16] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Otolaryngol, Shenzhen, Peoples R China

[17] Capital Med Univ, Beijing Tongren Hosp, Dept Allergy, Beijing, Peoples R China

来源：

JOURNAL OF THORACIC DISEASE | 2021年 / 13卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Chronic rhinosinusitis (CRS); corticosteroids; efficacy; safety; transnasal nebulization; MUCOSAL ATOMIZATION DEVICE; ENDOSCOPIC SINUS SURGERY; AQUEOUS NASAL SPRAY; INTRANASAL CORTICOSTEROIDS; BUDESONIDE RESPULES; ALLERGIC RHINITIS; DRUG-DELIVERY; FLUTICASONE; PREGNANCY; POLYPOSIS;

D O I：

10.21037/jtd-21-1142

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Corticosteroids are efficacious in treating chronic rhinosinusitis (CRS), but concerns on the potential side effects remain, especially for long-term usage of systemic corticosteroids. Accumulated evidence shows that transnasal nebulization may be a reasonable solution in balancing both efficacy and safety. However, no consensus or guideline has been formulated on the use of steroid transnasal nebulization in treating CRS. The consensus is achieved through literature review and exchange of Chinese experts in Group of Otorhinolaryngology and Ophthalmology, Chinese Society of Allergy (CSA). This document covers the development, equipment, pharmacological mechanism, and evidence-based efficacy and safety, as well as the special concern of the application of steroid transnasal nebulization during the coronavirus disease (COVID-19) pandemic. The expert consensus clarifies the application of steroid transnasal nebulization in treating CRS and common comorbidities during the perioperative and postoperative periods.

引用

页码：6217 / 6229

页数：13

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