The tripartite motif family identifies cell compartments

被引：1154
作者：
Reymond, A
Meroni, G
Fantozzi, A
Merla, G
Cairo, S
Luzi, L
Riganelli, D
Zanaria, E
Messali, S
Cainarca, S
Guffanti, A
Minucci, S
Pelicci, PG
Ballabio, A
机构：
[1] TIGEM, Milan, Italy
[2] Univ Perugia, Internal Med & Oncol Sci Inst, I-06100 Perugia, Italy
[3] European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy
[4] Uiv Vita & Salute, Milan, Italy
来源：
EMBO JOURNAL | 2001年 / 20卷 / 09期
关键词：
cell compartmentalization; functional genomics; nuclear bodies; RBCC; tripartite motif;
D O I：
10.1093/emboj/20.9.2140
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM), A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.
引用
收藏
页码：2140 / 2151
页数：12
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