Transcriptome Analysis Identifies LINC00152 as a Biomarker of Early Relapse and Mortality in Acute Lymphoblastic Leukemia

被引：20

作者：

Alberto Barcenas-Lopez, Diego ^{[1
]}

Carlos Nunez-Enriquez, Juan ^{[2
]}

Hidalgo-Miranda, Alfredo ^{[3
]}

Omar Beltran-Anaya, Fredy ^{[4
]}

Ismael May-Hau, Didier ^{[5
]}

Jimenez-Hernandez, Elva ^{[6
]}

Carolina Bekker-Mendez, Vilma ^{[7
]}

Flores-Lujano, Janet ^{[2
]}

Medina-Sanson, Aurora ^{[8
]}

Liliana Tamez-Gomez, Edna ^{[9
]}

Hugo Lopez-Garcia, Victor ^{[10
]}

Ramon Lara-Ramos, Jose ^{[11
]}

Nancy Nunez-Villegas, Nora ^{[6
]}

Gabriel Penaloza-Gonzalez, Jose ^{[12
]}

Victoria Flores-Villegas, Luz ^{[13
]}

Amador-Sanchez, Raquel ^{[14
]}

Martha Espinosa-Elizondo, Rosa ^{[15
]}

Alfonso Martin-Trejo, Jorge ^{[16
]}

Margarita Velazquez-Avina, Martha ^{[12
]}

Elizabeth Merino-Pasaye, Laura ^{[13
]}

Luisa Perez-Saldivar, Maria ^{[2
]}

Aldebaran Duarte-Rodriguez, David ^{[2
]}

Refugio Torres-Nava, Jose ^{[17
]}

Cortes-Herrera, Beatriz ^{[15
]}

Anastacia Solis-Labastida, Karina ^{[16
]}

Itamar Gonzalez-Avila, Ana ^{[14
]}

Denisse Santillan-Juarez, Jessica ^{[18
]}

Jimena Garcia-Velazquez, Alejandra ^{[18
]}

Rosas-Vargas, Haydee ^{[19
]}

Mata-Rocha, Minerva ^{[19
]}

Alejandro Sepulveda-Robles, Omar ^{[19
]}

Manuel Mejia-Arangure, Juan ^{[2
,20
]}

Jimenez-Morales, Silvia ^{[3
]}

机构：

[1] Univ Nacl Autonoma Mexico, Posgrad Ciencias Biol, Programa Doctorado, Mexico City 04510, DF, Mexico

[2] UMAE Hosp Pediat Dr Silvestre Frenk Freund, Inst Mexicano Seguro Social, Unidad Invest Med Epidemiol Clin, Ctr Med Nacl Siglo XXI, Mexico City 06720, DF, Mexico

[3] Inst Nacl Med Genom INMEGEN, Lab Genom Canc, Mexico City 14610, DF, Mexico

[4] Univ Nacl Autonoma Mexico, Programa Doctorado Ciencias Biomed, Mexico City 04510, DF, Mexico

[5] Univ Nacl Autonoma Mexico, Programa Maestria Invest Clin Expt Salud, Mexico City 04510, DF, Mexico

[6] Hosp Gen Gaudencio Gonzalez Garza, Ctr Med Nacl La Raza, Serv Hematol Pediat, IMSS, Mexico City 02990, DF, Mexico

[7] Hosp Infectol Dr Daniel Mendez Hernandez, Ctr Med Nacl La Raza, IMSS, Unidad Invest Med Inmunol & Infectol, Mexico City 02990, DF, Mexico

[8] Secretaria Salud SS, Serv Hematooncol, Hosp Infantil Mexico Federico Gomez, Mexico City 06720, DF, Mexico

[9] Secretaria Salud SS, Serv Hematooncol, Hosp Infantil Tamaulipas, Cd Victoria Tamaulipas 87070, Mexico

[10] Secretaria Salud SS, Serv Ortopedia Pediat, Hosp Infantil Tamaulipas, Cd Victoria Tamaulipas 87070, Mexico

[11] Secretaria Salud SS, Dept Genet, Hosp Infantil Tamaulipas, Cd Victoria Tamaulipas 87070, Mexico

[12] Secretaria Salud SS, Serv Oncopediat, Hosp Juarez Mexico, Mexico City 07760, DF, Mexico

[13] ISSSTE, Serv Hematol Pediat, Ctr Med Nacl 20 Noviembre, Mexico City 03100, DF, Mexico

[14] Hosp Gen Reg 1 Dr Carlos McGregor Sanchez Navarro, IMSS, Mexico City 03103, DF, Mexico

[15] Secretaria Salud SS, Hosp Gen Mexico Dr Eduardo Liceaga, Serv Hematol Pediat, Mexico City 06720, DF, Mexico

[16] UMAE Hosp Pediat Dr Silvestre Frenk Freund, IMSS, Serv Hematol Pediat, Ctr Med Nacl Siglo XXI, Mexico City 06720, DF, Mexico

[17] Secretaria Salud DF, Serv Oncol, Hosp Pediat Moctezuma, Mexico City 15530, DF, Mexico

[18] Hosp Reg 1 Octubre, Serv Hematooncol Pediat, ISSSTE, Mexico City 07300, DF, Mexico

[19] UMAE Hosp Pediat Dr Silvestre Frenk Freund, IMSS, Unidad Invest Genet Humana, Ctr Med Nacl Siglo XXI, Mexico City 06720, DF, Mexico

[20] IMSS, Coordinac Invest Salud, Mexico City 06720, DF, Mexico

来源：

GENES | 2020年 / 11卷 / 03期

关键词：

acute lymphoblastic leukemia; long noncoding RNA; LINC00152; LINC001013; early relapse; microarray expression analysis; LONG NONCODING RNAS; MEDIATED DOWN-REGULATION; ACUTE MYELOID-LEUKEMIA; CANCER; EXPRESSION; CHILDREN; LOC100130476; PROGRESSION; RESISTANCE; APOPTOSIS;

D O I：

10.3390/genes11030302

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Evidence showing the role of long non-coding RNAs (lncRNAs) in leukemogenesis have emerged in the last decade. It has been proposed that these genes can be used as diagnosis and/or prognosis biomarkers in childhood acute lymphoblastic leukemia (ALL). To know if lncRNAs are associated with early relapse and early mortality, a microarray-based gene expression analysis in children with B-lineage ALL (B-ALL) was conducted. Cox regression analyses were performed. Hazard ratios (HR) and 95% confidence intervals (95% CI) were calculated. LINC00152 and LINC01013 were among the most differentially expressed genes in patients with early relapse and early mortality. For LINC00152 high expression, the risks of relapse and death were HR: 4.16 (95% CI: 1.46-11.86) and HR: 1.99 (95% CI: 0.66-6.02), respectively; for LINC01013 low expression, the risks of relapse and death were HR: 3.03 (95% CI: 1.14-8.05) and HR: 6.87 (95% CI: 1.50-31.48), respectively. These results were adjusted by NCI risk criteria and chemotherapy regimen. The lncRNA-mRNA co-expression analysis showed that LINC00152 potentially regulates genes involved in cell substrate adhesion and peptidyl-tyrosine autophosphorylation biological processes. The results of the present study point out that LINC00152 could be a potential biomarker of relapse in children with B-ALL.

引用

页数：18

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