Small Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop

被引：10

作者：

Akkina, Ramesh ^{[1
]}

Barber, Daniel L. ^{[2
]}

Bility, Moses T. ^{[3
]}

Bissig, Karl-Dimiter ^{[4
]}

Burwitz, Benjamin J. ^{[5
]}

Eichelberg, Katrin ^{[2
]}

Endsley, Janice J. ^{[6
]}

Garcia, J. Victor ^{[7
]}

Hafner, Richard ^{[2
]}

Karakousis, Petros C. ^{[8
]}

Korba, Brent E. ^{[9
]}

Koshy, Rajen ^{[2
]}

Lambros, Chris ^{[2
]}

Menne, Stephan ^{[9
]}

Nuermberger, Eric L. ^{[8
]}

Ploss, Alexander ^{[10
]}

Podell, Brendan K. ^{[1
]}

Poluektova, Larisa Y. ^{[11
,12
]}

Sanders-Beer, Brigitte E. ^{[2
]}

Subbian, Selvakumar ^{[13
]}

Wahl, Angela ^{[7
]}

机构：

[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

[2] NIAID, NIH, Bethesda, MD 20892 USA

[3] Univ Pittsburgh, Dept Infect Dis & Microbiol, Pittsburgh, PA USA

[4] Duke Univ, Dept Pediat, Durham, NC 27706 USA

[5] Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Beaverton, OR USA

[6] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[7] Univ North Carolina Chapel Hill, Ctr AIDS Res, Div Infect Dis, Chapel Hill, NC USA

[8] Johns Hopkins Univ, Sch Med, Ctr TB Res, Div Infect Dis, Baltimore, MD USA

[9] Georgetown Univ, Dept Microbiol & Immunol, Washington, DC USA

[10] Princeton Univ, Dept Mol Biol, Princeton, NJ USA

[11] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE USA

[12] Univ Nebraska Med Ctr, Translat Mouse Model Core Facil, Omaha, NE USA

[13] Rutgers State Univ, New Jersey Med Sch, Publ Hlth Res Inst, Newark, NJ USA

来源：

CURRENT HIV RESEARCH | 2020年 / 18卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HIV; AIDS; co-infections; HBV; tuberculosis; animal models; PULMONARY GRANULOMAS; HUMAN HEPATOCYTES; MOUSE MODELS; GUINEA-PIGS; INFECTION; THERAPY; LIVER; MICE; REPOPULATION; PATHOGENESIS;

D O I：

10.2174/1570162X18666191223114019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The main advantage of animal models of infectious diseases over in vitro studies is the gain in the understanding of the complex dynamics between the immune system and the pathogen. While small animal models have practical advantages over large animal models, it is crucial to be aware of their limitations. Although the small animal model at least needs to be susceptible to the pathogen under study to obtain meaningful data, key elements of pathogenesis should also be reflected when compared to humans. Well-designed small animal models for HIV, hepatitis viruses and tuberculosis require, additionally, a thorough understanding of the similarities and differences in the immune responses between humans and small animals and should incorporate that knowledge into the goals of the study. To discuss these considerations, the NIAID hosted a workshop on 'Small Animal Models for HIV, Hepatitis B, and Tuberculosis' on May 30, 2019. Highlights of the workshop are outlined below.

引用

页码：19 / 28

页数：10

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