Influence of carvedilol on the benefits of physical training in patients with moderate chronic heart failure

Aims: To evaluate prospectively the impact of carvedilol on a short-term physical training program in stable patients with moderate chronic heart failure (CHF), and to analyze parameters predictive of improvement after training. Methods and results: Thirty-eight patients with CHF were referred for cardiac rehabilitation. Etiology was ischemic in 26 patients, dilated in 12 patients and left ventricular ejection fraction was < 35%. Patients were classified into three groups: group 1 (n = 14) = ACE inhibitors, diuretics and digitalis; group 2 (n = 11)= idem group 1 + cardioselective beta-blocker; group 3 (n = 13)= idem group 1+ carvedilol. Exercise tests with VO2 measurement were performed before and after a 4-week exercise training program. Patients with carvedilol experienced a 16.6% increase in peak VO2 which was similar to the 13.9% increase in the group with cardioselective beta-blocker and to the 18.5% in the group without beta-blocker. Moreover non-ischemic etiology of CHF was the only parameter predictive of improvement after training (P = 0.02). Conclusions: Addition of carvedilol did not alter benefits of a short-term physical training program in patients with moderate CHF. No baseline characteristic except for etiology of CHF was predictive of a response to training. (C) 2001 European Society of Cardiology. All rights reserved.