Apolipoprotein E as a risk factor for coronary heart disease: A genetic and molecular biology approach

被引：53
作者：
deKnijff, P
Havekes, LM
机构：
[1] TNO PG,GAUBIUS LAB,LEIDEN,NETHERLANDS
[2] LEIDEN UNIV,MGC DEPT HUMAN GENET,SYLVIUS LAB,2300 RA LEIDEN,NETHERLANDS
来源：
CURRENT OPINION IN LIPIDOLOGY | 1996年 / 7卷 / 02期
关键词：
D O I：
10.1097/00041433-199604000-00002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
For a long time it has been suggested that apolipoprotein E(4) is a major risk factor for coronary heart disease although indisputable proof has been lacking. However, context-dependent influences of apolipoprotein E polymorphism on the risk for coronary heart disease have been reported; that is, depending on ethnic origin, gender and lifestyle, apolipoprotein E(4) confers a major risk factor for coronary heart disease.
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页码：59 / 63
页数：5
相关论文
共 41 条
[1]   TREATMENT OF SEVERE HYPERCHOLESTEROLEMIA IN APOLIPOPROTEIN E-DEFICIENT MICE BY BONE-MARROW TRANSPLANTATION [J].
BOISVERT, WA ;
SPANGENBERG, J ;
CURTISS, LK .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (02) :1118-1124
[2]  
DALLONGEVILLE J, 1992, J LIPID RES, V33, P447
[3]   APOLIPOPROTEIN EPSILON-4 IS NOT A GENETIC RISK FACTOR FOR CORONARY-ARTERY DISEASE OR RESTENOSIS AFTER PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY [J].
DAMARAJU, S ;
YU, QT ;
SAFAVI, F ;
MARIAN, AJ .
AMERICAN JOURNAL OF CARDIOLOGY, 1995, 75 (16) :1181-1183
[4]   APOLIPOPROTEIN-E POLYMORPHISM AND ATHEROSCLEROSIS [J].
DAVIGNON, J ;
GREGG, RE ;
SING, CF .
ARTERIOSCLEROSIS, 1988, 8 (01) :1-21
[5]  
DEANDRADE M, 1995, AM J HUM GENET, V56, P1379
[6]   LIPOPROTEIN PROFILE OF A GREENLAND INUIT POPULATION - INFLUENCE OF ANTHROPOMETRIC VARIABLES, APO-E AND A4 POLYMORPHISM, AND LIFE-STYLE [J].
DEKNIJFF, P ;
JOHANSEN, LG ;
ROSSENEU, M ;
FRANTS, RR ;
JESPERSEN, J ;
HAVEKES, LM .
ARTERIOSCLEROSIS AND THROMBOSIS, 1992, 12 (12) :1371-1379
[7]   GENETIC-HETEROGENEITY OF APOLIPOPROTEIN-E AND ITS INFLUENCE ON PLASMA-LIPID AND LIPOPROTEIN LEVELS [J].
DEKNIJFF, P ;
VANDENMAAGDENBERG, AMJM ;
FRANTS, RR ;
HAVEKES, LM .
HUMAN MUTATION, 1994, 4 (03) :178-194
[8]  
DEKNIJFF P, 1992, LANCET, V340, P1351
[9]   SUSCEPTIBILITY TO DIET-INDUCED ATHEROSCLEROSIS IN TRANSGENIC MICE EXPRESSING A DYSFUNCTIONAL HUMAN APOLIPOPROTEIN E(ARG 112,CYS142) [J].
FAZIO, S ;
SANAN, DA ;
LEE, YL ;
JI, ZS ;
MAHLEY, RW ;
RALL, SC .
ARTERIOSCLEROSIS AND THROMBOSIS, 1994, 14 (11) :1873-1879
[10]   APOLIPOPROTEIN-E DEFICIENCY LEADS TO CUTANEOUS FOAM CELL-FORMATION IN MICE [J].
FEINGOLD, KR ;
ELIAS, PM ;
MAN, MQ ;
FARTASCH, M ;
ZHANG, SH ;
MAEDA, N .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 104 (02) :246-250
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