Tacrolimus in the Treatment of Ocular Diseases

被引：58

作者：

Zhai, Jiajie ^{[1
,2
]}

Gu, Jianjun ^{[1
]}

Yuan, Jin ^{[1
]}

Chen, Jiaqi ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China

[2] Inst Ophthalmol & Visual Sci Guangdong Prov, Guangzhou, Guangdong, Peoples R China

来源：

BIODRUGS | 2011年 / 25卷 / 02期

关键词：

VERSUS-HOST-DISEASE; CORNEAL GRAFT-REJECTION; HIGH-RISK CORNEAL; EXPERIMENTAL AUTOIMMUNE UVEORETINITIS; VERNAL KERATOCONJUNCTIVITIS; INTRAVITREAL INJECTION; CYCLOSPORINE-A; PANCREAS TRANSPLANTATION; IMMUNOSUPPRESSANT FK506; NEUROPROTECTIVE ACTIONS;

D O I：

10.2165/11587010-000000000-00000

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tacrolimus (FK506) has been used successfully as a systemic immunomodulator for more than 2 decades, and numerous studies have investigated its mechanisms of action. Systemic and topical tacrolimus have been investigated as treatments for ocular surface disorders that may have an immune-based inflammatory component. In these studies, tacrolimus has shown efficacy in corneal graft rejection, inflammatory conjunctival and corneal diseases, uveitis, and graft-versus-host disease. As these disorders are often refractory to other available treatments, ophthalmic or systemic tacrolimus is a welcome nontoxic adjunct or replacement to potentially toxic topical or systemic immunosuppressive therapies.

引用

页码：89 / 103

页数：15

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