Immune response against rickettsiae: lessons from murine infection models

被引：27
|
作者：
Osterloh, Anke [1 ]
机构：
[1] Bernhard Nocht Inst Trop Med, Hamburg, Germany
来源：
MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 2017年 / 206卷 / 06期
关键词：
Rickettsiae; Immunity; Immunopathology; SPOTTED-FEVER GROUP; HUMAN ENDOTHELIAL-CELLS; NF-KAPPA-B; BRILL-ZINSSER-DISEASE; EXPERIMENTAL SCRUB TYPHUS; TISSUE FACTOR EXPRESSION; CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; ACTIN-BASED MOTILITY; NITRIC-OXIDE;
D O I：
10.1007/s00430-017-0514-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Rickettsiae are small intracellular bacteria that can cause life-threatening febrile diseases. Rickettsioses occur worldwide with increasing incidence. Therefore, a vaccine is highly desired. A prerequisite for the development of a vaccine is the knowledge of the immune response against these bacteria, in particular protective immunity. In recent years murine models of rickettsial infections have been established, and the study of immune response against rickettsiae in mice provided many new insights into protective and pathological immune reactions. This review summarizes the current knowledge about immune mechanisms in protection and pathology in rickettsial infections.
引用
收藏
页码：403 / 417
页数：15
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