Characterisation of human saliva as a platform for oral dissolution medium development

被引：114

作者：

Gittings, Sally ^{[1
]}

Turnbull, Neil ^{[2
]}

Henry, Brian ^{[2
]}

Roberts, Clive J. ^{[1
]}

Gershkovich, Pavel ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England

[2] Pfizer Drug Prod Design, WRD Pharmaceut Sci, London, England

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2015年 / 91卷

基金：

英国工程与自然科学研究理事会;

关键词：

Human saliva; Taste masking; Dissolution; Biorelevant medium; Physicochemical characteristics; Oral cavity; STIMULATED WHOLE SALIVA; FLOW-RATE; BUFFERING CAPACITY; DOSAGE FORMS; GASTROINTESTINAL-TRACT; SURFACE-TENSION; IN-VITRO; DRUG SOLUBILITY; SOLID-SURFACES; PH;

D O I：

10.1016/j.ejpb.2015.01.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Human saliva is a biological fluid of great importance in the field of dissolution testing. However, until now, no consensus has been reached on its key characteristics relevant to dissolution testing. As a result, it is difficult to select or develop an in vitro dissolution medium to best represent human saliva. In this study, the pH, buffer capacity, surface tension, viscosity and flow rate of both unstimulated (US) and stimulated (SS) human saliva were investigated in order to provide a platform of reference for future dissolution studies using simulated salivary fluids. Age and gender related differences in a sample size of 30 participants for each parameter were investigated. Significant differences were established between US and SS for all characteristics except surface tension. Therefore, the requirement for using two simulated salivary fluids should be considered when developing an oral dissolution model. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：16 / 24

页数：9

共 74 条

[1] Time-dependent interfacial tension of whole saliva and saliva-bacteria mixes
Adamczyk, E
Arnebrant, T
Glantz, PO
[J]. ACTA ODONTOLOGICA SCANDINAVICA, 1997, 55 (06) : 384 - 389
[2] The distribution of oral mucosal pH values in healthy saliva secretors
Aframian, D. J.
Davidowitz, T.
Benoliel, R.
[J]. ORAL DISEASES, 2006, 12 (04) : 420 - 423
[3] Relationship between quantitative assessments of salivary buffering capacity and ion activity product for hydroxyapatite in relation to cariogenic potential
Aiuchi, H.
Kitasako, Y.
Fukuda, Y.
Nakashima, S.
Burrow, M. F.
Tagami, J.
[J]. AUSTRALIAN DENTAL JOURNAL, 2008, 53 (02) : 167 - 171
[4] [Anonymous], 2013, BRIT NATL FORMULARY, V65th
[5] Aulton M., 2007, AULTONS PHARM CHURCH
[6] The technologies used for developing orally disintegrating tablets: A review
Badgujar, Bhatu P.
Mundada, Atish S.
[J]. ACTA PHARMACEUTICA, 2011, 61 (02) : 117 - 139
[7] CHARACTERIZATION OF ORAL INVIVO FILMS FORMED ON DIFFERENT TYPES OF SOLID-SURFACES
BAIER, RE
GLANTZ, PO
[J]. ACTA ODONTOLOGICA SCANDINAVICA, 1978, 36 (05) : 289 - 301
[8] Banakar UV., 1992, Pharmaceutical Dissolution Testing
[9] The buffer capacity and buffer systems of human whole saliva measured without loss of CO2
Bardow, A
Moe, D
Nyvad, B
Nauntofte, B
[J]. ARCHIVES OF ORAL BIOLOGY, 2000, 45 (01) : 1 - 12
[10] Saliva flow rate, buffer capacity, and pH of autistic individuals
Bassoukou, Ivy Haralambos
Nicolau, Jose
dos Santos, Maria Teresa
[J]. CLINICAL ORAL INVESTIGATIONS, 2009, 13 (01) : 23 - 27

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