Vaccines for viral and bacterial pathogens causing acute gastroenteritis: Part II: Vaccines for Shigella, Salmonella, enterotoxigenic E. coli (ETEC) enterohemorragic E. coli (EHEC) and Campylobacter jejuni

被引：30

作者：

O'Ryan, Miguel ^{[1
]}

Vidal, Roberto ^{[1
]}

del Canto, Felipe ^{[1
]}

Carlos Salazar, Juan ^{[1
]}

Montero, David ^{[1
]}

机构：

[1] Univ Chile, Fac Med, Microbiol & Mycol Program, Inst Biomed Sci, Santiago 7, Chile

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2015年 / 11卷 / 03期

关键词：

acute diarrhea; Campylobacter; E; coli; ETEC; enteric pathogens; gastroenteritis; norovirus; rotavirus; Shigella; Salmonella; STEC; V; cholera; vaccines; O-SPECIFIC POLYSACCHARIDE; HEAT-LABILE TOXIN; HEMOLYTIC-UREMIC SYNDROME; WHOLE-CELL VACCINE; DYSENTERIAE TYPE-1 VACCINE; PROTEIN CONJUGATE VACCINE; PLACEBO-CONTROLLED TRIAL; B-SUBUNIT VACCINE; GUINEA-PIG MODEL; ESCHERICHIA-COLI;

D O I：

10.1080/21645515.2015.1011578

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In Part II we discuss the following bacterial pathogens: Shigella, Salmonella (non-typhoidal), diarrheogenic E. coli (enterotoxigenic and enterohemorragic) and Campylobacter jejuni. In contrast to the enteric viruses and Vibrio cholerae discussed in Part I of this series, for the bacterial pathogens described here there is only one licensed vaccine, developed primarily for Vibrio cholerae and which provides moderate protection against enterotoxigenic E. coli (ETEC) (Dukoral (R)), as well as a few additional candidates in advanced stages of development for ETEC and one candidate for Shigella spp. Numerous vaccine candidates in earlier stages of development are discussed.

引用

页码：601 / 619

页数：19

共 195 条

[81] Two studies evaluating the safety and immunogenicity of a live, attenuated Shigella flexneri 2a vaccine (SC602) and excretion of vaccine organisms in North American volunteers [J].

Katz, DE ;

Coster, TS ;

Wolf, MK ;

Trespalacios, FC ;

Cohen, D ;

Robins, G ;

Hartman, AB ;

Venkatesan, MM ;

Taylor, DN ;

Hale, TL .

INFECTION AND IMMUNITY, 2004, 72 (02) :923-930

[82] Development of a live oral attaching and effacing Escherichia coli vaccine candidate using Vibrio cholerae CVD 103-HgR as antigen vector [J].

Keller, Rogeria ;

Hilton, Tamara D. ;

Rios, Hernam ;

Boedeker, Edgar C. ;

Kaper, James B. .

MICROBIAL PATHOGENESIS, 2010, 48 (01) :1-8

[83] A genetic hybrid of the Campylobacter jejuni flaA gene with LT-B of Escherichia coli and assessment of the efficacy of the hybrid protein as an oral chicken vaccine [J].

Khoury, CA ;

Meinersmann, RJ .

AVIAN DISEASES, 1995, 39 (04) :812-820

[84]

Kim YJ, 2013, CURR PHARM BIOTECHNO, V14, P903

[85] Investigational vaccine for Escherichia coli O157:: Phase I study of O157 O-specific polysaccharide Pseudomonas aeruginosa recombinant exoprotein A conjugates in adults [J].

Konadu, EY ;

Parke, JC ;

Tran, HT ;

Bryla, DA ;

Robbins, JB ;

Szu, SC .

JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (02) :383-387

[86] VERO RESPONSE TO A CYTOTOXIN OF ESCHERICHIA-COLI [J].

KONOWALCHUK, J ;

SPEIRS, JI ;

STAVRIC, S .

INFECTION AND IMMUNITY, 1977, 18 (03) :775-779

[87] Shigellosis update: advancing antibiotic resistance, investment empowered vaccine development, and green bananas [J].

Kosek, Margaret ;

Yori, Pablo Penataro ;

Paredes Olortegui, Maribel .

CURRENT OPINION IN INFECTIOUS DISEASES, 2010, 23 (05) :475-480

[88] Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study [J].

Kotloff, Karen L. ;

Nataro, James P. ;

Blackwelder, William C. ;

Nasrin, Dilruba ;

Farag, Tamer H. ;

Panchalingam, Sandra ;

Wu, Yukun ;

Sow, Samba O. ;

Sur, Dipika ;

Breiman, Robert F. ;

Faruque, Abu S. G. ;

Zaidi, Anita K. M. ;

Saha, Debasish ;

Alonso, Pedro L. ;

Tamboura, Boubou ;

Sanogo, Doh ;

Onwuchekwa, Uma ;

Manna, Byomkesh ;

Ramamurthy, Thandavarayan ;

Kanungo, Suman ;

Ochieng, John B. ;

Omore, Richard ;

Oundo, Joseph O. ;

Hossain, Anowar ;

Das, Sumon K. ;

Ahmed, Shahnawaz ;

Qureshi, Shahida ;

Quadri, Farheen ;

Adegbola, Richard A. ;

Antonio, Martin ;

Hossain, M. Jahangir ;

Akinsola, Adebayo ;

Mandomando, Inacio ;

Nhampossa, Tacilta ;

Acacio, Sozinho ;

Biswas, Kousick ;

O'Reilly, Ciara E. ;

Mintz, Eric D. ;

Berkeley, Lynette Y. ;

Muhsen, Khitam ;

Sommerfelt, Halvor ;

Robins-Browne, Roy M. ;

Levine, Myron M. .

LANCET, 2013, 382 (9888) :209-222

[89] Phase I evaluation of ΔvirG Shigella sonnei live, attenuated, oral vaccine strain WRSS1 in healthy adults [J].

Kotloff, KL ;

Taylor, DN ;

Sztein, MB ;

Wasserman, SS ;

Losonsky, GA ;

Nataro, JP ;

Venkatesan, M ;

Hartman, A ;

Picking, WD ;

Katz, DE ;

Campbell, JD ;

Levine, MM ;

Hale, TL .

INFECTION AND IMMUNITY, 2002, 70 (04) :2016-2021

[90]

Kotloff KL, 1999, B WORLD HEALTH ORGAN, V77, P651

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