Vaccines for viral and bacterial pathogens causing acute gastroenteritis: Part II: Vaccines for Shigella, Salmonella, enterotoxigenic E. coli (ETEC) enterohemorragic E. coli (EHEC) and Campylobacter jejuni

被引：29

作者：

O'Ryan, Miguel ^{[1
]}

Vidal, Roberto ^{[1
]}

del Canto, Felipe ^{[1
]}

Carlos Salazar, Juan ^{[1
]}

Montero, David ^{[1
]}

机构：

[1] Univ Chile, Fac Med, Microbiol & Mycol Program, Inst Biomed Sci, Santiago 7, Chile

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2015年 / 11卷 / 03期

关键词：

acute diarrhea; Campylobacter; E; coli; ETEC; enteric pathogens; gastroenteritis; norovirus; rotavirus; Shigella; Salmonella; STEC; V; cholera; vaccines; O-SPECIFIC POLYSACCHARIDE; HEAT-LABILE TOXIN; HEMOLYTIC-UREMIC SYNDROME; WHOLE-CELL VACCINE; DYSENTERIAE TYPE-1 VACCINE; PROTEIN CONJUGATE VACCINE; PLACEBO-CONTROLLED TRIAL; B-SUBUNIT VACCINE; GUINEA-PIG MODEL; ESCHERICHIA-COLI;

D O I：

10.1080/21645515.2015.1011578

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In Part II we discuss the following bacterial pathogens: Shigella, Salmonella (non-typhoidal), diarrheogenic E. coli (enterotoxigenic and enterohemorragic) and Campylobacter jejuni. In contrast to the enteric viruses and Vibrio cholerae discussed in Part I of this series, for the bacterial pathogens described here there is only one licensed vaccine, developed primarily for Vibrio cholerae and which provides moderate protection against enterotoxigenic E. coli (ETEC) (Dukoral (R)), as well as a few additional candidates in advanced stages of development for ETEC and one candidate for Shigella spp. Numerous vaccine candidates in earlier stages of development are discussed.

引用

页码：601 / 619

页数：19

共 195 条

[1] Bacterial outer membrane vesicles and vaccine applications [J].