Deletion of Mycobacterium tuberculosis sigma factor E results in delayed time to death with bacterial persistence in the lungs of aerosol-infected mice

被引：64

作者：

Ando, M ^{[1
]}

Yoshimatsu, T ^{[1
]}

Ko, C ^{[1
]}

Converse, PJ ^{[1
]}

Bishai, WR ^{[1
]}

机构：

[1] Johns Hopkins Univ, Johns Hopkins Sch Med, Ctr TB Res, Dept Med, Baltimore, MD 21231 USA

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 12期

关键词：

D O I：

10.1128/IAI.71.12.7170-7172.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The stress-induced extracytoplasmic sigma factor E (SigE) of Mycobacterium tuberculosis shows increased expression after heat shock, sodium dodecyl sulfate treatment, and oxidative stress, as well as after phagocytosis in macrophages. We report that deletion of sigE results in delayed lethality in mice without a significant reduction of bacterial numbers in lungs.

引用

页码：7170 / 7172

页数：3

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