Deletion of Mycobacterium tuberculosis sigma factor E results in delayed time to death with bacterial persistence in the lungs of aerosol-infected mice

被引：64

作者：

Ando, M ^{[1
]}

Yoshimatsu, T ^{[1
]}

Ko, C ^{[1
]}

Converse, PJ ^{[1
]}

Bishai, WR ^{[1
]}

机构：

[1] Johns Hopkins Univ, Johns Hopkins Sch Med, Ctr TB Res, Dept Med, Baltimore, MD 21231 USA

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 12期

关键词：

D O I：

10.1128/IAI.71.12.7170-7172.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The stress-induced extracytoplasmic sigma factor E (SigE) of Mycobacterium tuberculosis shows increased expression after heat shock, sodium dodecyl sulfate treatment, and oxidative stress, as well as after phagocytosis in macrophages. We report that deletion of sigE results in delayed lethality in mice without a significant reduction of bacterial numbers in lungs.

引用

页码：7170 / 7172

页数：3

共 18 条

[1] Failure of the Mycobacterium bovis BCG vaccine:: Some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis [J].

Brandt, L ;

Cunha, JF ;

Olsen, AW ;

Chilima, B ;

Hirsch, P ;

Appelberg, R ;

Andersen, P .

INFECTION AND IMMUNITY, 2002, 70 (02) :672-678

[2] Construction and characterization of a Mycobacterium tuberculosis mutant lacking the alternate sigma factor gene, sigF [J].

Chen, P ;

Ruiz, RE ;

Li, Q ;

Silver, RF ;

Bishai, WR .

INFECTION AND IMMUNITY, 2000, 68 (10) :5575-5580

[3] Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence [J].

Cole, ST ;

Brosch, R ;

Parkhill, J ;

Garnier, T ;

Churcher, C ;

Harris, D ;

Gordon, SV ;

Eiglmeier, K ;

Gas, S ;

Barry, CE ;

Tekaia, F ;

Badcock, K ;

Basham, D ;

Brown, D ;

Chillingworth, T ;

Connor, R ;

Davies, R ;

Devlin, K ;

Feltwell, T ;

Gentles, S ;

Hamlin, N ;

Holroyd, S ;

Hornby, T ;

Jagels, K ;

Krogh, A ;

McLean, J ;

Moule, S ;

Murphy, L ;

Oliver, K ;

Osborne, J ;

Quail, MA ;

Rajandream, MA ;

Rogers, J ;

Rutter, S ;

Seeger, K ;

Skelton, J ;

Squares, R ;

Squares, S ;

Sulston, JE ;

Taylor, K ;

Whitehead, S ;

Barrell, BG .

NATURE, 1998, 393 (6685) :537-+

[4] THE STREPTOMYCES-COELICOLOR-WHIB GENE ENCODES A SMALL TRANSCRIPTION FACTOR-LIKE PROTEIN DISPENSABLE FOR GROWTH BUT ESSENTIAL FOR SPORULATION [J].

DAVIS, NK ;

CHATER, KF .

MOLECULAR & GENERAL GENETICS, 1992, 232 (03) :351-358

[5] A stationary-phase stress-response sigma factor from Mycobacterium tuberculosis [J].

DeMaio, J ;

Zhang, Y ;

Ko, C ;

Young, DB ;

Bishai, WR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (07) :2790-2794

[6] A mycobacterial extracytoplasmic sigma factor involved in survival following heat shock and oxidative stress [J].

Fernandes, ND ;

Wu, QL ;

Kong, DQ ;

Puyang, XL ;

Garg, S ;

Husson, RN .

JOURNAL OF BACTERIOLOGY, 1999, 181 (14) :4266-4274

[7] Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains [J].

Fleischmann, RD ;

Alland, D ;

Eisen, JA ;

Carpenter, L ;

White, O ;

Peterson, J ;

DeBoy, R ;

Dodson, R ;

Gwinn, M ;

Haft, D ;

Hickey, E ;

Kolonay, JF ;

Nelson, WC ;

Umayam, LA ;

Ermolaeva, M ;

Salzberg, SL ;

Delcher, A ;

Utterback, T ;

Weidman, J ;

Khouri, H ;

Gill, J ;

Mikula, A ;

Bishai, W ;

Jacobs, WR ;

Venter, JC ;

Fraser, CM .

JOURNAL OF BACTERIOLOGY, 2002, 184 (19) :5479-5490

[8] Sigma factors of Mycobacterium tuberculosis [J].

Gomez, JE ;

Chen, JM ;

Bishai, WR .

TUBERCLE AND LUNG DISEASE, 1997, 78 (3-4) :175-183

[9] Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS) [J].

Graham, JE ;

Clark-Curtiss, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11554-11559

[10] Differential expression of sigE by Mycobacterium tuberculosis during intracellular growth [J].

Jensen-Cain, DM ;

Quinn, FD .

MICROBIAL PATHOGENESIS, 2001, 30 (05) :271-278

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