Striatal astrocytes produce neuroblasts in an excitotoxic model of Huntington's disease

被引:87
作者
Nato, Giulia [1 ,2 ]
Caramello, Alessia [1 ,2 ]
Trova, Sara [1 ,2 ]
Avataneo, Valeria [1 ,2 ]
Rolando, Chiara [3 ]
Taylor, Verdon [3 ]
Buffo, Annalisa [2 ,4 ]
Peretto, Paolo [1 ,2 ]
Luzzati, Federico [1 ,2 ]
机构
[1] Univ Turin, Dept Life Sci & Syst Biol DBIOS, I-10123 Turin, Italy
[2] NICO, I-10043 Orbassano, Italy
[3] Univ Basel, Dept Biomedecin, CH-4050 Basel, Switzerland
[4] Univ Turin, Dept Neurosci Rita Levi Montalcini, I-10126 Turin, Italy
来源
DEVELOPMENT | 2015年 / 142卷 / 05期
关键词
Neural stem cells; Parenchymal progenitors; Stem cell quiescence; Lesion-induced neurogenesis; Huntington's disease; Mouse; NEURAL STEM-CELLS; TRANSCRIPTION FACTOR SP8; SUBVENTRICULAR ZONE; ADULT NEUROGENESIS; PROGENITOR CELLS; GENERATE NEURONS; INJURED BRAIN; GLIAL-CELLS; NICHE; PURIFICATION;
D O I
10.1242/dev.116657
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In the adult brain, subsets of astrocytic cells residing in well-defined neurogenic niches constitutively generate neurons throughout life. Brain lesions can stimulate neurogenesis in otherwise non-neurogenic regions, but whether local astrocytic cells generate neurons in these conditions is unresolved. Here, through genetic and viral lineage tracing in mice, we demonstrate that striatal astrocytes become neurogenic following an acute excitotoxic lesion. Similar to astrocytes of adult germinal niches, these activated parenchymal progenitors express nestin and generate neurons through the formation of transit amplifying progenitors. These results shed new light on the neurogenic potential of the adult brain parenchyma.
引用
收藏
页码:840 / 845
页数:6
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