Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives

被引：63

作者：

Miro, Javier ^{[1
]}

del Pozo, Carlos ^{[1
]}

Toste, F. Dean ^{[2
]}

Fustero, Santos ^{[1
,3
]}

机构：

[1] Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Spain

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[3] Ctr Invest Principe Felipe, Lab Mol Organ, Valencia 46012, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 31期

关键词：

alkenes; fluorine; palladium; reaction mechanisms; synthetic methods; ALPHA-AMINO-ACIDS; C-H BONDS; BENZYLIC FLUORINATION; NUCLEOPHILIC FLUORINATION; SELECTIVE FLUORINATION; REDUCTIVE ELIMINATION; PHASE-TRANSFER; BORONIC ACIDS; FLUORIDE; ALKENES;

D O I：

10.1002/anie.201603046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The site-selective palladium-catalyzed three-component coupling of deactivated alkenes, arylboronic acids, and N-fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step-economical approach to the stereoselective beta-fluorination of alpha,beta-unsaturated systems.

引用

页码：9045 / 9049

页数：5

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