Dipeptide-functionalized MIL-101(Fe) as efficient material for ibuprofen delivery

被引：12

作者：

Asadi, Fatemeh Rajab ^{[1
]}

Hamzavi, Seyedeh Fazileh ^{[2
]}

Shahverdizadeh, Gholam Hossein ^{[3
]}

Ilkhchi, Mahdi Ghasedi ^{[3
]}

Hosseinzadeh-Khanmiri, Rahim ^{[3
]}

机构：

[1] Shahid Beheshti Univ, Dept Phys, Tehran, Iran

[2] Islamic Azad Univ, Sci & Res Branch, Dept Marine Biol, Tehran, Iran

[3] Islamic Azad Univ, Tabriz Branch, Dept Chem, Tabriz, Iran

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2018年 / 32卷 / 12期

关键词：

characterization; dipeptide; functionalization; ibuprofen delivery; MIL-101(Fe); METAL-ORGANIC-FRAMEWORK; DRUG-DELIVERY; MESOPOROUS SILICA; NANOPARTICLES; ADSORPTION; MOF; COMPOSITES; CATALYST; RELEASE; CARBON;

D O I：

10.1002/aoc.4552

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two derivatives of a dipeptide-functionalized metal-organic framework were synthesized through isocyanide-based multi-component reactions from amine-containing MIL-101(Fe). The functionalized materials were characterized by means of Fourier transform infrared spectroscopy, X-ray diffraction Brunauer-Emmett-Teller measurements, thermogravimetric analysis, elemental analysis and scanning electron microscopy. The performances of these functionalized MIL-101(Fe) materials with different functions were evaluated for ibuprofen delivery during six days, showing a good ability for adsorption of significant content of the drug and very slow release.

引用

页数：6

共 36 条

[1] Cell attachment evaluation of the immobilized bioactive peptide on a nanographene oxide composite [J].