Steatosis and NASH in type 2 diabetes

被引:45
作者
Hu, Mengyue [1 ,2 ]
Phan, Franck [1 ,2 ]
Bourron, Olivier [1 ,2 ,3 ,4 ]
Ferre, Pascal [1 ,2 ]
Foufelle, Fabienne [1 ,2 ,3 ,4 ]
机构
[1] Sorbonne Univ, INSERM UMRS 1138, Ctr Rech Cordeliers, F-75006 Paris, France
[2] Univ Paris Diderot, Ctr Rech Cordeliers, Sorbonne Paris Cite, Univ Paris Descartes, F-75006 Paris, France
[3] AP HP, Dept Endocrinol Nutr & Diabet, Paris, France
[4] Hop La Pitie Salpetriere, AP HP, ICAN, Paris, France
关键词
Steatosis; NASH; Insulin resistance; Inflammation; Lipotoxicity; Type; 2; diabetes; FATTY LIVER-DISEASE; DE-NOVO LIPOGENESIS; NF-KAPPA-B; INSULIN-RESISTANCE; HEPATIC STEATOSIS; NONALCOHOLIC STEATOHEPATITIS; IKK-BETA; RISK; OBESITY; MICE;
D O I
10.1016/j.biochi.2017.10.019
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets. (C) 2017 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
引用
收藏
页码:37 / 41
页数:5
相关论文
共 50 条
  • [41] Serum Mac-2 Binding Protein Glycosylation Isomer Concentrations Are Associated With Incidence of Type 2 Diabetes
    Higashioka, Mayu
    Hirakawa, Yoichiro
    Hata, Jun
    Honda, Takanori
    Sakata, Satoko
    Shibata, Mao
    Kitazono, Takanari
    Osawa, Haruhiko
    Ninomiya, Toshiharu
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2023, 108 (07) : E425 - E433
  • [42] Circulating levels of selected adipokines in women with gestational diabetes and type 2 diabetes
    Karasek, David
    Kubickova, Veronika
    Krystynik, Ondrej
    Goldmannova, Dominika
    Cibickova, Lubica
    Schovanek, Jan
    JOURNAL OF APPLIED BIOMEDICINE, 2020, 18 (2-3) : 54 - 60
  • [43] Euterpe oleracea Mart. (acai) seed extract associated with exercise training reduces hepatic steatosis in type 2 diabetic male rats
    de Bem, Graziele Freitas
    da Costa, Cristiane Aguiar
    Cristino Cordeiro, Viviane da Silva
    Santos, Izabelle Barcellos
    Reis Marins de Carvalho, Lenize Costa
    Soares, Ricardo de Andrade
    Ribeiro, Jessica Honorato
    Vieira de Souza, Marcelo Augusto
    da Cunha Sousa, Pergentino Jose
    Ognibene, Dayane Teixeira
    Resende, Angela Castro
    de Moura, Roberto Soares
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2018, 52 : 70 - 81
  • [44] Glycogenic hepatopathy associated with hepatic steatosis in type 1 diabetes
    Teasdale, Stephanie
    Dong, Xin
    Griffin, Alison
    Clark, Paul James
    Nisbet, Janelle
    Morton, Adam
    Phillips, Liza
    Sullivan, Mitchell Anthony
    Galloway, Graham
    JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2024, 38 (11)
  • [45] Effect of Insulin Versus Triple Oral Therapy on the Progression of Hepatic Steatosis in Type 2 Diabetes
    Lingvay, Ildiko
    Roe, Erin D.
    Duong, Jonathan
    Leonard, David
    Szczepaniak, Lidia S.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2012, 60 (07) : 1059 - 1063
  • [46] Identification of Genipin as a Potential Treatment for Type 2 Diabetes
    Wu, Yajun
    Wang, Yao
    Liu, Dongmin
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (03)
  • [47] Genetic Susceptibility of Type 2 Diabetes and Metabolic Syndrome
    Ercegovic, Vladimir
    Dzimbeg, Monika
    Gelemanovic, Andrea
    DIABETOLOGY, 2025, 6 (02):
  • [48] From Metabolic Syndrome to Type 2 Diabetes in Youth
    Iafusco, Dario
    Franceschi, Roberto
    Maguolo, Alice
    Nuzio, Salvatore Guercio
    Crino, Antonino
    Delvecchio, Maurizio
    Iughetti, Lorenzo
    Maffeis, Claudio
    Calcaterra, Valeria
    Manco, Melania
    CHILDREN-BASEL, 2023, 10 (03):
  • [49] Common metabolic features of hypertension and type 2 diabetes
    Usui, Isao
    HYPERTENSION RESEARCH, 2023, 46 (05) : 1227 - 1233
  • [50] A Review of Type 2 Diabetes Mellitus Predisposing Genes
    Yahaya, Tajudeen O.
    Salisu, Titilola F.
    CURRENT DIABETES REVIEWS, 2020, 16 (01) : 52 - 61