Steatosis and NASH in type 2 diabetes

被引：45
作者：
Hu, Mengyue [1 ,2 ]
Phan, Franck [1 ,2 ]
Bourron, Olivier [1 ,2 ,3 ,4 ]
Ferre, Pascal [1 ,2 ]
Foufelle, Fabienne [1 ,2 ,3 ,4 ]
机构：
[1] Sorbonne Univ, INSERM UMRS 1138, Ctr Rech Cordeliers, F-75006 Paris, France
[2] Univ Paris Diderot, Ctr Rech Cordeliers, Sorbonne Paris Cite, Univ Paris Descartes, F-75006 Paris, France
[3] AP HP, Dept Endocrinol Nutr & Diabet, Paris, France
[4] Hop La Pitie Salpetriere, AP HP, ICAN, Paris, France
来源：
BIOCHIMIE | 2017年 / 143卷
关键词：
Steatosis; NASH; Insulin resistance; Inflammation; Lipotoxicity; Type; 2; diabetes; FATTY LIVER-DISEASE; DE-NOVO LIPOGENESIS; NF-KAPPA-B; INSULIN-RESISTANCE; HEPATIC STEATOSIS; NONALCOHOLIC STEATOHEPATITIS; IKK-BETA; RISK; OBESITY; MICE;
D O I：
10.1016/j.biochi.2017.10.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets. (C) 2017 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
引用
收藏
页码：37 / 41
页数：5
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