Hepatitis E Virus Infection: Neurological Manifestations and Pathophysiology

被引：19

作者：

Lhomme, Sebastien ^{[1
,2
]}

Abravanel, Florence ^{[1
,2
]}

Cintas, Pascal ^{[3
]}

Izopet, Jacques ^{[1
,2
]}

机构：

[1] Univ Toulouse, Infinity, CNRS, INSERM,UPS, F-31300 Toulouse, France

[2] CHU Toulouse, Hop Purpan, Lab Virol, F-31300 Toulouse, France

[3] CHU Toulouse, Serv Neurol, Hop Purpan, F-31300 Toulouse, France

来源：

PATHOGENS | 2021年 / 10卷 / 12期

关键词：

hepatitis E virus; neurological manifestations; extra-hepatic manifestations; GUILLAIN-BARRE-SYNDROME; NEURALGIC AMYOTROPHY; PATIENT; RIBAVIRIN; FRANCE; REPLICATION; ASSOCIATION; DISORDERS; OUTBREAK; VARIANT;

D O I：

10.3390/pathogens10121582

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis E virus (HEV) is the first cause of viral hepatitis in the world. While the water-borne HEV genotypes 1 and 2 are found in developing countries, HEV genotypes 3 and 4 are endemic in developed countries due to the existence of animal reservoirs, especially swine. An HEV infection produces many extra-hepatic manifestations in addition to liver symptoms, especially neurological disorders. The most common are neuralgic amyotrophy or Parsonage-Turner syndrome, Guillain-Barre syndrome, myelitis, and encephalitis. The pathophysiology of the neurological injuries due to HEV remains uncertain. The immune response to the virus probably plays a role, but direct virus neurotropism could also contribute to the pathophysiology. This review describes the main neurological manifestations and their possible pathogenic mechanisms.

引用

页数：11

共 97 条

[61] Endoplasmic Reticulum Stress Induced Synthesis of a Novel Viral Factor Mediates Efficient Replication of Genotype-1 Hepatitis E Virus [J].

Nair, Vidya P. ;

Anang, Saumya ;

Subramani, Chandru ;

Madhvi, Abhilasha ;

Bakshi, Karishma ;

Srivastava, Akriti ;

Shalimar ;

Nayak, Baibaswata ;

Kumar, Ranjith C. T. ;

Surjit, Milan .

PLOS PATHOGENS, 2016, 12 (04)

[62] Chronic Hepatitis After Hepatitis E Virus Infection in a Patient With Non-Hodgkin Lymphoma Taking Rituximab [J].

Ollier, Laurence ;

Tieulie, Nathalie ;

Sanderson, Frederick ;

Heudier, Philippe ;

Giordanengo, Valerie ;

Fuzibet, Jean-Gabriel ;

Nicand, Elisabeth .

ANNALS OF INTERNAL MEDICINE, 2009, 150 (06) :430-+

[63] Liver function disturbances in Guillain-Barre syndrome: A prospective longitudinal study in 100 patients [J].

Oomes, PG ;

vanderMeche, FGA ;

Kleyweg, RP ;

Meulstee, J ;

vandenHoven, RM ;

Schmitz, PIM ;

Busch, HFM ;

Lee, ML ;

deJager, AEJ ;

vanWeerden, TW ;

Oey, PL ;

TerBruggen, JP ;

Stam, J ;

deVisser, BWO ;

Franke, CL ;

Vredeveld, JW ;

Arts, WFM ;

deWeerd, AW ;

vanKasteren, BJ ;

Heimans, JJ ;

Polman, C ;

Strijers, RPM ;

deVriesLeenders, EM ;

Jansen, FNH ;

Frenken, CWGM ;

Verhagen, WIM ;

vonderBrand, HJ ;

Sinnige, HAW ;

vanLeusden, JA ;

deCoul, AAWO ;

Schellens, RLAA ;

Korten, JJ ;

Sinnige, LGF ;

Tavy, DLJ ;

Wattendorf, AK ;

Howeler, CJ ;

Spaans, F ;

Hooijkaas, H ;

Banffer, JRJ .

NEUROLOGY, 1996, 46 (01) :96-100

[64] Acute autochthonous hepatitis E in western patients with underlying chronic liver disease: A role for ribavirin? [J].

Peron, J. M. ;

Dalton, H. ;

Izopet, J. ;

Kamar, N. .

JOURNAL OF HEPATOLOGY, 2011, 54 (06) :1323-1324

[65] Neurologic Disorders in Immunocompetent Patients with Autochthonous Acute Hepatitis E [J].

Perrin, H. Blasco ;

Cintas, P. ;

Abravanel, F. ;

Gerolami, R. ;

d'Alteroche, L. ;

Raynal, J. -N. ;

Alric, L. ;

Dupuis, E. ;

Prudhomme, L. ;

Vaucher, E. ;

Couzigou, R. ;

Liversain, J. -M. ;

Bureau, C. ;

Vinel, J. -P. ;

Kamar, N. ;

Izopet, J. ;

Peron, J. -M. .

EMERGING INFECTIOUS DISEASES, 2015, 21 (11) :1928-1934

[66] Chronic Hepatitis E in Rheumatology and Internal Medicine Patients: A Retrospective Multicenter European Cohort Study [J].

Pischke, Sven ;

Peron, Jean-Marie ;

von Wulffen, Moritz ;

von Felden, Johann ;

zu Siederdissen, Christoph Hoener ;

Fournier, Sophie ;

Luetgehetmann, Marc ;

Iking-Konert, Christoph ;

Bettinger, Dominik ;

Par, Gabriella ;

Thimme, Robert ;

Cantagrel, Alain ;

Lohse, Ansgar W. ;

Wedemeyer, Heiner ;

de Man, Robert ;

Mallet, Vincent .

VIRUSES-BASEL, 2019, 11 (02)

[67] Disseminated inflammation of the central nervous system associated with acute hepatitis E: a case report [J].

Rahmig, Jan ;

Grey, Arne ;

Berning, Marco ;

Schaefer, Jochen ;

Lesser, Martin ;

Reichmann, Heinz ;

Puetz, Volker ;

Barlinn, Kristian ;

Siepmann, Timo .

BMC NEUROLOGY, 2020, 20 (01)

[68] The global burden of hepatitis E virus genotypes 1 and 2 in 2005 [J].

Rein, David B. ;

Stevens, Gretchen A. ;

Theaker, Jordan ;

Wittenborn, John S. ;

Wiersma, Steven T. .

HEPATOLOGY, 2012, 55 (04) :988-997

[69] The entire genome sequence of hepatitis E virus genotype 3 isolated from a patient with neuralgic amyotrophy [J].

Rianthavorn, Pornpimol ;

Thongmee, Chittima ;

Limpaphayom, Noppachart ;

Komolmit, Piyawat ;

Theamboonlers, Apiradee ;

Poovorawan, Yong .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2010, 42 (05) :395-400

[70] Neurologic complications of acute hepatitis E virus infection [J].

Ripellino, Paolo ;

Pasi, Emanuela ;

Melli, Giorgia ;

Staedler, Claudio ;

Fraga, Monserrat ;

Moradpour, Darius ;

Sahli, Roland ;

Aubert, Vincent ;

Martinetti, Gladys ;

Bihl, Florian ;

Bernasconi, Enos ;

Terziroli Beretta-Piccoli, Benedetta ;

Cerny, Andreas ;

Dalton, Harry Roland ;

Zehnder, Cinzia ;

Mathis, Barbara ;

Zecca, Chiara ;

Disanto, Giulio ;

Kaelin-Lang, Alain ;

Gobbi, Claudio .

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2020, 7 (01) :E643

← 1 2 3 4 5 6 7 8 9 10 →