Hepatitis E Virus Infection: Neurological Manifestations and Pathophysiology

被引：19

作者：

Lhomme, Sebastien ^{[1
,2
]}

Abravanel, Florence ^{[1
,2
]}

Cintas, Pascal ^{[3
]}

Izopet, Jacques ^{[1
,2
]}

机构：

[1] Univ Toulouse, Infinity, CNRS, INSERM,UPS, F-31300 Toulouse, France

[2] CHU Toulouse, Hop Purpan, Lab Virol, F-31300 Toulouse, France

[3] CHU Toulouse, Serv Neurol, Hop Purpan, F-31300 Toulouse, France

来源：

PATHOGENS | 2021年 / 10卷 / 12期

关键词：

hepatitis E virus; neurological manifestations; extra-hepatic manifestations; GUILLAIN-BARRE-SYNDROME; NEURALGIC AMYOTROPHY; PATIENT; RIBAVIRIN; FRANCE; REPLICATION; ASSOCIATION; DISORDERS; OUTBREAK; VARIANT;

D O I：

10.3390/pathogens10121582

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis E virus (HEV) is the first cause of viral hepatitis in the world. While the water-borne HEV genotypes 1 and 2 are found in developing countries, HEV genotypes 3 and 4 are endemic in developed countries due to the existence of animal reservoirs, especially swine. An HEV infection produces many extra-hepatic manifestations in addition to liver symptoms, especially neurological disorders. The most common are neuralgic amyotrophy or Parsonage-Turner syndrome, Guillain-Barre syndrome, myelitis, and encephalitis. The pathophysiology of the neurological injuries due to HEV remains uncertain. The immune response to the virus probably plays a role, but direct virus neurotropism could also contribute to the pathophysiology. This review describes the main neurological manifestations and their possible pathogenic mechanisms.

引用

页数：11

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