E-Cadherin and Alpha-Catenin Expression in Normal, Hyperplastic and Neoplastic Endometrium

被引：0

作者：

Carico, Elisabetta ^{[1
]}

Atlante, Marco ^{[3
]}

Giarnieri, Enrico ^{[1
]}

Raffa, Salvatore ^{[2
]}

Bucci, Barbara ^{[4
]}

Giovagnoli, Maria Rosaria ^{[1
]}

Vecchione, Aldo ^{[5
]}

机构：

[1] Univ Roma La Sapienza, Fac Med, UOD Cytopathol 2, I-00198 Rome, Italy

[2] Univ Roma La Sapienza, Fac Med, UOC Diagnost Cellulare 2, I-00198 Rome, Italy

[3] Fabia Mater, Div Ginecol, I-00171 Rome, Italy

[4] S Pietro Fatebenefratelli Hosp, AFAR Ctr Ric, I-00189 Rome, Italy

[5] Ist Tumori G Pascale, Direz Sci, I-80131 Naples, Italy

来源：

ANTICANCER RESEARCH | 2010年 / 30卷 / 12期

关键词：

alpha-Catenin; E-cadherin; down-regulation; immunohistochemistry; endometrium; TYROSINE KINASE SUBSTRATE; OVARIAN TUMOR-CELLS; BETA-CATENIN; DIFFERENTIAL EXPRESSION; PROTEIN INTERACTIONS; ADHESION MOLECULES; GAMMA-CATENIN; HUMAN CANCER; CARCINOMA; INVASIVENESS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this study was to determine whether modulation of expression of cell adhesion molecules may occur in neoplastic transformation of endometrial epithelium. Materials and Methods: E-Cadherin and alpha-catenin protein expression were evaluated by immunohistochemistry in 124 biopsies representative of normal, hyperplastic and neoplastic endometrium. Results: In normal endometrium (proliferative, secretive and atrophic endometrium) strong homogeneous, E-cadherin and alpha-catenin reactivity was found; 58.3% and 66.6% of biopsies representative of simple hyperplastic endometrium were homogeneously positive for E-cadherin and alpha-catenin, respectively, whereas no samples representative of atypical hyperplasia showed evidence of homogeneous E-cadherin or alpha-catenin expression. No expression of homogeneous E-cadherin was seen in endometrial adenocarcinomas; alpha-catenin homogeneous immunostaining was observed in 2 G1 and 2 G2 out of 22 adenocarcinoma samples (18.2%). A homogeneous co-expression of both molecules was seen only in normal (70%) and simple hyperplastic (46%) endometrium. Conclusion: These results suggest that E-cadherin and alpha-catenin down-regulation might be associated with neoplastic transformation of endometrial tissues.

引用

页码：4993 / 4997

页数：5

共 35 条

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