SK-PC-B70M from Pulsatilla koreana improves scopolamine-induced impairments of memory consolidation and spatial working memory

被引：23

作者：

Han, Chang-Kyun ^{[2
,3
]}

Park, Yang Hae ^{[2
]}

Jin, Da-Qing ^{[4
,5
]}

Hwang, Yoo Kyeong ^{[1
]}

Oh, Ki-Bong ^{[3
]}

Han, Jung-Soo ^{[1
]}

机构：

[1] Konkuk Univ, Dept Biol Sci, Seoul 143701, South Korea

[2] SK Chem, Life Sci R&D Ctr, Suwon 440745, Gyeonggi Do, South Korea

[3] Seoul Natl Univ, Dept Agr Biotechnol, Seoul 151921, South Korea

[4] Inje Univ, Grad Program Neurosci, Taejon 305804, South Korea

[5] Inje Univ, IBST, Taejon 305804, South Korea

来源：

BRAIN RESEARCH | 2007年 / 1184卷

关键词：

working memory; scopolamine; cholinergic; consolidation;

D O I：

10.1016/j.brainres.2007.09.084

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have shown that hederacolchiside-E from Pulsatilla koreana has neuroprotective effects and cognition-enhancing effects. Subsequently, in the current study, we demonstrate that oral administrations of oleanolic-glycoside saponins enriched fraction from P. koreana, designated as SK-PC-B70M, improve impairments in memory consolidation and spatial working memory by systemic injection of scopolamine, a muscarinic cholinergic receptor antagonist. In a step-through avoidance task, when the rats stepped through a dark chamber in a shuttle box, an electric shock was given and then SK-PC-B70M was administered 30 min later. Twenty-four hours later, the rats were placed in an illuminated chamber. The rats with SK-PC-B70M treatments showed longer response latencies than rats with only scopolamine. Spatial working memory was measured with a trial-unique matching-to-place task in a water maze which assessed memory for place information over varying lengths of delays. Three delay lengths were used: 1 min, 5 min, and 3 h. In comparison with the control rats, the rats with scopolamine treatments took significantly longer to find the platform in the second trial with 1- and 5-min delays. The rats with both scopolamine and SK-PC-B70M had significantly less search error compared with the rats with scopolamine only. These findings indicate that SK-PC-B70M has effects on reversing impairments of memory consolidation and working memory impairments induced by scopolamine. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：254 / 259

页数：6

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