Improving surface and mechanical properties of alginate films by using ethanol as a co-solvent during external gelation

被引：103
作者：
Li, Jiwei [1 ]
He, Jinmei [1 ]
Huang, Yudong [1 ]
Li, Dalong [1 ]
Chen, Xiaotong [2 ]
机构：
[1] Harbin Inst Technol, Sch Chem Engn & Technol, Harbin 150001, Peoples R China
[2] Weihai JieRui Med Co Ltd, Weihai 264209, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2015年 / 123卷
关键词：
Alginate; External gelation; Calcium; Film; Ethanol; NATAMYCIN RELEASE; CROSS-LINKING; GELS; NA+;
D O I：
10.1016/j.carbpol.2015.01.040
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Alginate films were prepared by solution casting method and further ionically crosslinked in a calcium chloride (CaCl2) water solution containing different proportions (0-40% v/v) of ethanol as the co-solvent. The addition of ethanol into the CaCl2 water solution was found to improve the visual appearance, thickness, surface homogeneity, and mechanical properties of the films, which can be attributed to the reduced swelling degree of films during crosslinking process. Furthermore, Fourier transform infrared spectroscopy (FTIR) and energy dispersive spectroscopy (EDS) analysis indicated that the incorporation of ethanol into the crosslinking solution did not detract from the uniformity of crosslinking throughout the film matrix. However, the swelling degree and calcium content determination indicated that the Ca2+ crosslinking degree decreased when the ethanol proportion exceeded 30% v/v. Consequently, this study introduces a green, efficient, and simple technique for the preparation of calcium alginate films with excellent surface appearance and mechanical properties for pharmaceutical products. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：208 / 216
页数：9
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