Apolipoprotein E phenotype in demented patients in Greek population

被引：4

作者：

Hatzifilippou, Eleni ^{[1
]}

Banaki, Tania ^{[2
]}

Traka, Maria ^{[2
]}

Koutsouraki, Ephrosyni ^{[1
,2
]}

Costa, Vassiliki ^{[1
,2
]}

Baloyannis, Stavros J. ^{[1
,2
]}

机构：

[1] Aristotle Univ Thessaloniki, AHEPA Hosp, Dept Neurol 1, Neuropathol Lab, GR-54006 Thessaloniki, Greece

[2] Aristotle Univ Thessaloniki, Dept Neurol 1, Mem Clin, GR-54006 Thessaloniki, Greece

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2008年 / 118卷 / 01期

关键词：

Alzheimer's disease; ApoE genotype; apo e4 allele in Greece; apolipoprotein E; dementia in Greece; vascular dementia;

D O I：

10.1080/00207450601123498

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apolipoprotein E is a plasma protein, involved in the transport of lipids and their metabolism. The aim of this investigation was to correlate the ApoE phenotypes with the type and the severity of dementia in Greek demented patients. The investigation revealed that 72% of the patients have the E3/3 phenotype, but only 11% of them demonstrated the E3/2; 13% of the patients have the E4/3 phenotype and only 4% of them demonstrated the phenotype E4/4. The most severely demented patients corresponded to e4 allele. The present results indicate that the most common ApoE phenotype in Greek demented patients is E3/3.

引用

页码：163 / 172

页数：10

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