CYP2D6 polymorphisms are associated with effects of risperidone on neurocognitive performance in schizophrenia

被引：3
作者：
Zeng, Lei [1 ]
Kang, ChuanYuan [2 ]
Yuan, Jing [1 ]
Zhang, Yan [1 ]
Wei, Yujun [1 ]
Xu, Li [1 ]
Zhou, Fang [1 ]
Yang, JianZhong [1 ]
机构：
[1] Kunming Med Univ, Affiliated Hosp 2, Dept Psychiat, Kunming 650101, Yunnan, Peoples R China
[2] Kunming Med Univ, Affiliated Hosp 1, Dept Psychiat, Kunming 650032, Yunnan, Peoples R China
来源：
SCHIZOPHRENIA RESEARCH | 2017年 / 188卷
关键词：
Schizophrenia; CYP2D6; Risperidone; Cognition; Treatment response; DEBRISOQUINE; METABOLISM;
D O I：
10.1016/j.schres.2017.01.030
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
引用
收藏
页码：50 / 51
页数：2
相关论文
共 10 条
  • [1] Involvement of 5-HT2A receptor and a2-adrenoceptor blockade in the asenapine-induced elevation of prefrontal cortical monoamine outflow
    Franberg, Olivia
    Marcus, Monica M.
    Svensson, Torgny H.
    [J]. SYNAPSE, 2012, 66 (07) : 650 - 660
  • [2] Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat
    Grayson, B.
    Idris, N. F.
    Neill, J. C.
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2007, 184 (01) : 31 - 38
  • [3] JANSSEN PAJ, 1988, J PHARMACOL EXP THER, V244, P685
  • [4] INHERITED AMPLIFICATION OF AN ACTIVE GENE IN THE CYTOCHROME-P450 CYP2D LOCUS AS A CAUSE OF ULTRARAPID METABOLISM OF DEBRISOQUINE
    JOHANSSON, I
    LUNDQVIST, E
    BERTILSSON, L
    DAHL, ML
    SJOQVIST, F
    INGELMANSUNDBERG, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) : 11825 - 11829
  • [5] The role of CYP2D6 and ABCB1 pharmacogenetics in drug-na⟨ve patients with first-episode schizophrenia treated with risperidone
    Jovanovic, Nikolina
    Bozina, Nada
    Lovric, Mila
    Medved, Vesna
    Jakovljevic, Miro
    Peles, Alma Mihaljevic
    [J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2010, 66 (11) : 1109 - 1117
  • [6] Interaction of catechol-O-methyltransferase (COMT) Val108/158 Met genotype and risperidone treatment in Chinese Han patients with schizophrenia
    Kang, Chuan Yuan
    Xu, Xiu Feng
    Shi, Zhen Yu
    Yang, Jian Zhong
    Liu, Hua
    Xu, Hong Hui
    [J]. PSYCHIATRY RESEARCH, 2010, 176 (01) : 94 - 95
  • [7] Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine
    Marcucci, KA
    Pearce, RE
    Crespi, C
    Steimel, DT
    Leeder, JS
    Gaedigk, A
    [J]. DRUG METABOLISM AND DISPOSITION, 2002, 30 (05) : 595 - 601
  • [8] Molecular mechanisms of genetic polymorphisms of drug metabolism
    Meyer, UA
    Zanger, UM
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1997, 37 : 269 - 296
  • [9] Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects
    Sim, S. C.
    Kacevska, M.
    Ingelman-Sundberg, M.
    [J]. PHARMACOGENOMICS JOURNAL, 2013, 13 (01) : 1 - 11
  • [10] The influence of switching from risperidone to paliperidone on the extrapyramidal symptoms and cognitive function in elderly patients with schizophrenia: A preliminary open-label trial
    Suzuki, Hidenobu
    Gen, Keishi
    Inoue, Yuichi
    Hibino, Hiroyuki
    Mikami, Ayako
    Matsumoto, Hideo
    Mikami, Katsunaka
    [J]. INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, 2014, 18 (01) : 58 - 62
1