Genomic signatures of pancreatic adenosquamous carcinoma (PASC)

被引：45

作者：

Fang, Yuan ^{[1
,2
,3
]}

Su, Zhe ^{[4
,5
]}

Xie, Jing ^{[6
]}

Xue, Ruidong ^{[4
]}

Ma, Qi ^{[4
]}

Li, Yanmeng ^{[4
]}

Zhao, Yifan ^{[4
]}

Song, Zeshi ^{[7
]}

Lu, Xiongxiong ^{[1
,2
]}

Li, Hongwei ^{[2
]}

Peng, Chenghong ^{[1
,2
,3
]}

Bai, Fan ^{[4
]}

Shen, Baiyong ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Res Inst Pancreat Dis, Sch Med, Ruijin Hosp, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Pancreat Dis Ctr, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Inst Digest Surg, Sch Med, Ruijin Hosp, Shanghai, Peoples R China

[4] Peking Univ, Sch Life Sci, Biodynam Opt Imaging Ctr, Beijing, Peoples R China

[5] Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China

[6] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Pathol, Shanghai, Peoples R China

[7] Asclegen Biotechnol Inc, Shanghai, Peoples R China

来源：

JOURNAL OF PATHOLOGY | 2017年 / 243卷 / 02期

关键词：

pancreatic adenosquamous carcinoma (PASC); mixed cancer; TP53; 3p loss; CANCER; ABERRATIONS; STATISTICS;

D O I：

10.1002/path.4943

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In pancreatic cancer, pancreatic adenosquamous carcinoma (PASC) containing both ductal adenocarcinoma and squamous carcinoma in the same tumour represents similar to 4% of the total incidence. To date, the genomic features of this mixed tumour are still unknown. We analysed the genomes of 17 PASCs and 34 pancreatic ductal adenocarcinomas (PDACs), and showed that PASC carried highly enriched TP53 mutations and 3p loss as compared with PDAC. We also showed that adenomatous and squamous components of PASC harboured comparable genomic alterations, suggesting that the two cellular components develop from the same progenitor cancer cells. Our study has updated genomic knowledge to help with understanding mixed cancers of the pancreas. Copyright (C) 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：155 / 159

页数：5

共 15 条

[1] Genomic analyses identify molecular subtypes of pancreatic cancer
Bailey, Peter
Chang, David K.
Nones, Katia
Johns, Amber L.
Patch, Ann-Marie
Gingras, Marie-Claude
Miller, David K.
Christ, Angelika N.
Bruxner, Tim J. C.
Quinn, Michael C.
Nourse, Craig
Murtaugh, L. Charles
Harliwong, Ivon
Idrisoglu, Senel
Manning, Suzanne
Nourbakhsh, Ehsan
Wani, Shivangi
Fink, Lynn
Holmes, Oliver
Chin, Vencssa
Anderson, Matthew J.
Kazakoff, Stephen
Leonard, Conrad
Newell, Felicity
Waddell, Nick
Wood, Scott
Xu, Qinying
Wilson, Peter J.
Cloonan, Nicole
Kassahn, Karin S.
Taylor, Darrin
Quek, Kelly
Robertson, Alan
Pantano, Lorena
Mincarelli, Laura
Sanchez, Luis N.
Evers, Lisa
Wu, Jianmin
Pinese, Mark
Cowley, Mark J.
Jones, Marc D.
Colvin, Emily K.
Nagrial, Adnan M.
Humphrey, Emily S.
Chantrill, Lorraine A.
Mawson, Amanda
Humphris, Jeremy
Chou, Angela
Pajic, Marina
Scarlett, Christopher J.
[J]. NATURE, 2016, 531 (7592) : 47 - +
[2] Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma
Beroukhim, Rameen
Getz, Gad
Nghiemphu, Leia
Barretina, Jordi
Hsueh, Teli
Linhart, David
Vivanco, Igor
Lee, Jeffrey C.
Huang, Julie H.
Alexander, Sethu
Du, Jinyan
Kau, Tweeny
Thomas, Roman K.
Shah, Kinial
Soto, Horacio
Perner, Sven
Prensner, John
Debiasi, Ralph M.
Demichelis, Francesca
Hatton, Charlie
Rubin, Mark A.
Garraway, Levi A.
Nelson, Stan F.
Liau, Linda
Mischel, Paul S.
Cloughesy, Tim F.
Meyerson, Matthew
Golub, Todd A.
Lander, Eric S.
Mellinghoff, Ingo K.
Sellers, William R.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (50) : 20007 - 20012
[3] Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Biankin, Andrew V.
Waddell, Nicola
Kassahn, Karin S.
Gingras, Marie-Claude
Muthuswamy, Lakshmi B.
Johns, Amber L.
Miller, David K.
Wilson, Peter J.
Patch, Ann-Marie
Wu, Jianmin
Chang, David K.
Cowley, Mark J.
Gardiner, Brooke B.
Song, Sarah
Harliwong, Ivon
Idrisoglu, Senel
Nourse, Craig
Nourbakhsh, Ehsan
Manning, Suzanne
Wani, Shivangi
Gongora, Milena
Pajic, Marina
Scarlett, Christopher J.
Gill, Anthony J.
Pinho, Andreia V.
Rooman, Ilse
Anderson, Matthew
Holmes, Oliver
Leonard, Conrad
Taylor, Darrin
Wood, Scott
Xu, Qinying
Nones, Katia
Fink, J. Lynn
Christ, Angelika
Bruxner, Tim
Cloonan, Nicole
Kolle, Gabriel
Newell, Felicity
Pinese, Mark
Mead, R. Scott
Humphris, Jeremy L.
Kaplan, Warren
Jones, Marc D.
Colvin, Emily K.
Nagrial, Adnan M.
Humphrey, Emily S.
Chou, Angela
Chin, Venessa T.
Chantrill, Lorraine A.
[J]. NATURE, 2012, 491 (7424) : 399 - 405
[4] 415 Patients with Adenosquamous Carcinoma of the Pancreas: A Population-Based Analysis of Prognosis and Survival
Boyd, Casey A.
Benarroch-Gampel, Jaime
Sheffield, Kristin M.
Cooksley, Catherine D.
Riall, Taylor S.
[J]. JOURNAL OF SURGICAL RESEARCH, 2012, 174 (01) : 12 - 19
[5] Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
Cibulskis, Kristian
Lawrence, Michael S.
Carter, Scott L.
Sivachenko, Andrey
Jaffe, David
Sougnez, Carrie
Gabriel, Stacey
Meyerson, Matthew
Lander, Eric S.
Getz, Gad
[J]. NATURE BIOTECHNOLOGY, 2013, 31 (03) : 213 - 219
[6] Adenosquamous Versus Adenocarcinoma of the Pancreas: A Population-Based Outcomes Analysis
Katz, Matthew Harold G.
Taylor, Thomas H.
Al-Refaie, Waddah B.
Hanna, Mark H.
Imagawa, David K.
Anton-Culver, Hoda
Zell, Jason A.
[J]. JOURNAL OF GASTROINTESTINAL SURGERY, 2011, 15 (01) : 165 - 174
[7] Li H, 2009, BIOINFORMATICS, V25, P1094, DOI [10.1093/bioinformatics/btp100, 10.1093/bioinformatics/btp324]
[8] Cancer treatment and survivorship statistics, 2016
Miller, Kimberly D.
Siegel, Rebecca L.
Lin, Chun Chieh
Mariotto, Angela B.
Kramer, Joan L.
Rowland, Julia H.
Stein, Kevin D.
Alteri, Rick
Jemal, Ahmedin
[J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2016, 66 (04) : 271 - 289
[9] Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients
Ni, Xiaohui
Zhuo, Minglei
Su, Zhe
Duan, Jianchun
Gao, Yan
Wang, Zhijie
Zong, Chenghang
Bai, Hua
Chapman, Alec R.
Zhao, Jun
Xu, Liya
An, Tongtong
Ma, Qi
Wang, Yuyan
Wu, Meina
Sun, Yu
Wang, Shuhang
Li, Zhenxiang
Yang, Xiaodan
Yong, Jun
Su, Xiao-Dong
Lu, Youyong
Bai, Fan
Xie, X. Sunney
Wang, Jie
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (52) : 21083 - 21088
[10] RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
Niederst, Matthew J.
Sequist, Lecia V.
Poirier, John T.
Mermel, Craig H.
Lockerman, Elizabeth L.
Garcia, Angel R.
Katayama, Ryohei
Costa, Carlotta
Ross, Kenneth N.
Moran, Teresa
Howe, Emily
Fulton, Linnea E.
Mulvey, Hillary E.
Bernardo, Lindsay A.
Mohamoud, Farhiya
Miyoshi, Norikatsu
VanderLaan, Paul A.
Costa, Daniel B.
Jaenne, Pasi A.
Borger, Darrell R.
Ramaswamy, Sridhar
Shioda, Toshi
Iafrate, Anthony J.
Getz, Gad
Rudin, Charles M.
Mino-Kenudson, Mari
Engelman, Jeffrey A.
[J]. NATURE COMMUNICATIONS, 2015, 6

← 1 2 →