Versatile Hyperbranched Poly(β-hydrazide ester) Macromers as Injectable Antioxidative Hydrogels

被引：42

作者：

Xu, Qian ^{[1
]}

Venet, Manon ^{[2
]}

Wang, Wei ^{[3
]}

Creagh-Flynn, Jack ^{[1
]}

Wang, Xi ^{[1
]}

Li, Xiaolin ^{[1
]}

Gao, Yongsheng ^{[1
]}

Zhou, Dezhong ^{[1
]}

Zeng, Ming ^{[1
]}

Lara-Saez, Irene ^{[1
]}

Sigen, A. ^{[1
]}

Tai, Hongyun ^{[4
]}

Wang, Wenxin ^{[1
]}

机构：

[1] Univ Coll Dublin, Charles Inst Dermatol, Sch Med, Dublin 4, Ireland

[2] Claude Bernard Univ Lyon I, Dept Biol, Mol & Cellular Biol, Specialty Skin Biol, F-69622 Villeurbanne, France

[3] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300350, Peoples R China

[4] Bangor Univ, Sch Chem, Bangor LL57 2DG, Gwynedd, Wales

来源：

ACS APPLIED MATERIALS & INTERFACES | 2018年 / 10卷 / 46期

基金：

爱尔兰科学基金会;

关键词：

antioxidant; poly(beta-hydrazide ester); injectable; hydrogel; tissue engineering; POLY(BETA-AMINO ESTER); COMBINATORIAL LIBRARY; DEGRADATION; POLYMERS; DELIVERY; STRESS; DESIGN; OXYGEN; ROS;

D O I：

10.1021/acsami.8b15006

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Synthetic reactive oxygen species (ROS)-responsive biomaterials have emerged as a useful platform for regulating critical aspects of ROS-induced pathologies and can improve such hostile microenvironments. Here, we report a series of new hyperbranched poly(beta-hydrazide ester) macromers (HB-PBHEs) with disulfide moieties synthesized via an "A2 + B4" Michael addition approach. The three-dimensional structure of HB-PBHEs with multiacrylate end groups endows the macromers with rapid gelation capabilities to form (1) injectable hydrogels via cross-linking with thiolated hyaluronic acid and (2) robust UV-cross-linked hydrogels. The disulfide-containing macromers and hydrogels exhibit H2O2-responsive degradation compared with the counterparts synthesized by a dihydrazide monomer without disulfide moieties. The cell viability under a high ROS environment can be well-maintained under the protection of the disulfide containing hydrogels.

引用

页码：39494 / 39504

页数：11

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