DNA interactions with ruthenium(II) polypyridine complexes containing asymmetric ligands

被引：56

作者：

Chao, H ^{[1
]}

Ji, LN ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Minist Educ, Key Lab Gene Engn, Dept Chem, Guangzhou 510275, Peoples R China

来源：

BIOINORGANIC CHEMISTRY AND APPLICATIONS | 2005年 / 3卷 / 1-2期

关键词：

Ru(II) complexes; DNA; asymmetric ligands;

D O I：

10.1155/BCA.2005.15

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In an attempt to probe nucleic acid structures, numerous Ru(II) complexes with different ligands have been synthesized and investigated. In this contribution we focus on the DNA-binding properties of ruthenium(II) complexes containing asymmetric ligands that have attracted little attention in the past decades. The influences of the shape and size of the ligand on the binding modes, affinity, enantioselectivities and photocleavage of the complexes to DNA are described.

引用

页码：15 / 28

页数：14

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