A randomized controlled trial of visible-light therapy for the prevention of oral mucositis

被引：22

作者：

Elad, Sharon ^{[1
]}

Luboshitz-Shon, Noa ^{[1
]}

Cohen, Tehila ^{[1
]}

Wainchwaig, Elad ^{[1
]}

Shapira, Michael Y. ^{[2
]}

Resnick, Igor B. ^{[2
]}

Radiano, Ruth ^{[2
]}

Lubart, Rachel ^{[3
,4
]}

Or, Reuven ^{[2
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Sch Dent Med, Dept Oral Med, IL-91120 Jerusalem, Israel

[2] Hadassah Univ Med Ctr, Dept Bone Marrow Transplantat & Canc Immunotherap, Jerusalem, Israel

[3] Bar Ilan Univ, Dept Phys, Ramat Gan, Israel

[4] Bar Ilan Univ, Dept Chem, Ramat Gan, Israel

来源：

ORAL ONCOLOGY | 2011年 / 47卷 / 02期

关键词：

Low level laser therapy; Light; LLLT; Mucositis; Oral; Phototherapy; Prevention; Visible; LOW-ENERGY LASER; LOW-POWER LASER; CLINICAL-PRACTICE GUIDELINES; RADIATION-INDUCED MUCOSITIS; HELIUM-NEON LASER; TRANSPLANTATION; HEAD; PHOTOTHERAPY;

D O I：

10.1016/j.oraloncology.2010.11.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The objective of this study was to assess the efficacy of a novel visible-light therapy (VLT) device for the prevention of oral mucositis in hematopoietic stem cell transplantation (HSCT) patients. A VLT-device suitable for intra-oral use was applied to 20 patients undergoing HSCT. The study design was placebo-controlled, randomized and double-blind. Oral mucositis was assessed using the OMAS and WHO scales. Oral pain and acceptance levels were scored by the patient using a 10-step scale. Patients were evaluated once a week until day 21 post-HSCT. Mucositis rate, severity and pain score were compared. At the third visit, 1 week post-HSCT, mucositis rates were significantly lower in the treatment group (for both WHO and OMAS p = 0.02). Mucositis was also less severe in the treatment group (for WHO p = 0.01; for OMAS p = 0.01). Furthermore, the patients in the treatment group reported lower pain levels (p = 0.04). The treatment was well tolerated and highly accepted, with no reports of adverse events related to the device. These findings suggest that the VLT-device is safe and effective for the prevention of oral mucositis in patients undergoing HSCT. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：125 / 130

页数：6

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