A randomized controlled trial of visible-light therapy for the prevention of oral mucositis

被引:22
作者
Elad, Sharon [1 ]
Luboshitz-Shon, Noa [1 ]
Cohen, Tehila [1 ]
Wainchwaig, Elad [1 ]
Shapira, Michael Y. [2 ]
Resnick, Igor B. [2 ]
Radiano, Ruth [2 ]
Lubart, Rachel [3 ,4 ]
Or, Reuven [2 ]
机构
[1] Hebrew Univ Jerusalem, Hadassah Sch Dent Med, Dept Oral Med, IL-91120 Jerusalem, Israel
[2] Hadassah Univ Med Ctr, Dept Bone Marrow Transplantat & Canc Immunotherap, Jerusalem, Israel
[3] Bar Ilan Univ, Dept Phys, Ramat Gan, Israel
[4] Bar Ilan Univ, Dept Chem, Ramat Gan, Israel
关键词
Low level laser therapy; Light; LLLT; Mucositis; Oral; Phototherapy; Prevention; Visible; LOW-ENERGY LASER; LOW-POWER LASER; CLINICAL-PRACTICE GUIDELINES; RADIATION-INDUCED MUCOSITIS; HELIUM-NEON LASER; TRANSPLANTATION; HEAD; PHOTOTHERAPY;
D O I
10.1016/j.oraloncology.2010.11.013
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The objective of this study was to assess the efficacy of a novel visible-light therapy (VLT) device for the prevention of oral mucositis in hematopoietic stem cell transplantation (HSCT) patients. A VLT-device suitable for intra-oral use was applied to 20 patients undergoing HSCT. The study design was placebo-controlled, randomized and double-blind. Oral mucositis was assessed using the OMAS and WHO scales. Oral pain and acceptance levels were scored by the patient using a 10-step scale. Patients were evaluated once a week until day 21 post-HSCT. Mucositis rate, severity and pain score were compared. At the third visit, 1 week post-HSCT, mucositis rates were significantly lower in the treatment group (for both WHO and OMAS p = 0.02). Mucositis was also less severe in the treatment group (for WHO p = 0.01; for OMAS p = 0.01). Furthermore, the patients in the treatment group reported lower pain levels (p = 0.04). The treatment was well tolerated and highly accepted, with no reports of adverse events related to the device. These findings suggest that the VLT-device is safe and effective for the prevention of oral mucositis in patients undergoing HSCT. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:125 / 130
页数:6
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