Admixture analysis of age at onset in bipolar disorder

被引：43
|
作者：
Tozzi, Federica [1 ]
Manchia, Mirko [2 ]
Galwey, Nicholas W. [3 ]
Severino, Giovanni [2 ]
Del Zompo, Maria [2 ]
Day, Richard [4 ]
Matthews, Keith [4 ]
Strauss, John [5 ]
Kennedy, James L. [5 ]
McGuffin, Peter [6 ]
Vincent, John B. [5 ]
Farmer, Anne [6 ]
Muglia, Pierandrea [5 ]
机构：
[1] GlaxoSmithKline R&D, Genet, Div Genet, I-37135 Verona, Italy
[2] Univ Cagliari, Clin Psychopharmacol Ctr, Clin Pharmacol Sect, Dept Neurosci BB Brodie, I-09124 Cagliari, Italy
[3] GlaxoSmithKline R&D, Div Genet, Harlow, Essex, England
[4] Univ Dundee, Ninewells Hosp & Med Sch, Sect Psychiat & Behav Sci, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland
[5] CAMH, Dept Psychiat, Toronto, ON, Canada
[6] Kings Coll London, Inst Psychiat, MRC, Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England
来源：
PSYCHIATRY RESEARCH | 2011年 / 185卷 / 1-2期
关键词：
Affective disorders; Age at onset; Admixture analysis; Suicide; CLINICAL CHARACTERISTICS; 12-MONTH PREVALENCE; EPIDEMIOLOGY; DEPRESSION; LIFETIME; GENETICS; POLARITY; ILLNESS; FAMILY; RISK;
D O I：
10.1016/j.psychres.2009.11.025
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The aim of this study was to identify whether age at onset (MO) identifies Bipolar Disorder (BD) subtypes. and to test whether the subgroups were confirmed by different clinical profiles. Admixture analysis was applied to determine a model that best fit the observed distribution of MO in 964 BD patients. Three distributions of MO were identified, and age means were 16.1 (S.D. 4.2), 25.4 (S.D. 2.5) and 32.2 (S.D. 9.5) years. A significant increased rate of suicide attempts, Bipolar I (BD I) caseness, and depressive onset was observed in the early-onset group when compared to those with later-onset by means of chi(2). Findings from extant studies and our results are remarkably consistent in showing that BD can be subdivided into three groups based on MO distributions, and that early-onset is associated with higher rates of suicide attempts. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：27 / 32
页数：6
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