Admixture analysis of age at onset in bipolar disorder

被引：43

作者：

Tozzi, Federica ^{[1
]}

Manchia, Mirko ^{[2
]}

Galwey, Nicholas W. ^{[3
]}

Severino, Giovanni ^{[2
]}

Del Zompo, Maria ^{[2
]}

Day, Richard ^{[4
]}

Matthews, Keith ^{[4
]}

Strauss, John ^{[5
]}

Kennedy, James L. ^{[5
]}

McGuffin, Peter ^{[6
]}

Vincent, John B. ^{[5
]}

Farmer, Anne ^{[6
]}

Muglia, Pierandrea ^{[5
]}

机构：

[1] GlaxoSmithKline R&D, Genet, Div Genet, I-37135 Verona, Italy

[2] Univ Cagliari, Clin Psychopharmacol Ctr, Clin Pharmacol Sect, Dept Neurosci BB Brodie, I-09124 Cagliari, Italy

[3] GlaxoSmithKline R&D, Div Genet, Harlow, Essex, England

[4] Univ Dundee, Ninewells Hosp & Med Sch, Sect Psychiat & Behav Sci, Div Pathol & Neurosci, Dundee DD1 9SY, Scotland

[5] CAMH, Dept Psychiat, Toronto, ON, Canada

[6] Kings Coll London, Inst Psychiat, MRC, Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England

来源：

PSYCHIATRY RESEARCH | 2011年 / 185卷 / 1-2期

关键词：

Affective disorders; Age at onset; Admixture analysis; Suicide; CLINICAL CHARACTERISTICS; 12-MONTH PREVALENCE; EPIDEMIOLOGY; DEPRESSION; LIFETIME; GENETICS; POLARITY; ILLNESS; FAMILY; RISK;

D O I：

10.1016/j.psychres.2009.11.025

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The aim of this study was to identify whether age at onset (MO) identifies Bipolar Disorder (BD) subtypes. and to test whether the subgroups were confirmed by different clinical profiles. Admixture analysis was applied to determine a model that best fit the observed distribution of MO in 964 BD patients. Three distributions of MO were identified, and age means were 16.1 (S.D. 4.2), 25.4 (S.D. 2.5) and 32.2 (S.D. 9.5) years. A significant increased rate of suicide attempts, Bipolar I (BD I) caseness, and depressive onset was observed in the early-onset group when compared to those with later-onset by means of chi(2). Findings from extant studies and our results are remarkably consistent in showing that BD can be subdivided into three groups based on MO distributions, and that early-onset is associated with higher rates of suicide attempts. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：27 / 32

页数：6

共 50 条

[1] Admixture Analysis of Age of Onset in Bipolar Disorder and Impact of Anxiety Comorbidity
Pini, Stefano
Carpita, Barbara
Nardi, Benedetta
Abelli, Marianna
Amatori, Giulia
Cremone, Ivan
Dell'Osso, Liliana
CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (03)
[2] Admixture analysis of age at onset in first episode bipolar disorder
Nowrouzi, Behdin
McIntyre, Roger S.
MacQueen, Glenda
Kennedy, Sidney H.
Kennedy, James L.
Ravindran, Arun
Yatham, Lakshmi
De Luca, Vincenzo
JOURNAL OF AFFECTIVE DISORDERS, 2016, 201 : 88 - 94
[3] Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder
Golmard, J. -L.
Scott, J.
Etain, B.
Preisig, M.
Aubry, J. -M.
Henry, C.
Jamain, S.
Azorin, J. -M.
Leboyer, M.
Bellivier, F.
ACTA PSYCHIATRICA SCANDINAVICA, 2016, 133 (03) : 205 - 213
[4] Admixture analysis of age at onset in major depressive disorder
Zhu, Tina
De Luca, Vincenzo
Gallaugher, Laura Ashley
Woldeyohannes, Hanna O.
Soczynska, Joanna K.
Szymkowicz, Sarah
Muzina, David J.
Kennedy, Sidney H.
McIntyre, Roger S.
GENERAL HOSPITAL PSYCHIATRY, 2012, 34 (06) : 686 - 691
[5] Admixture analysis of age at symptom onset and age at disorder onset in a large sample of patients with obsessive-compulsive disorder
Albert, Umberto
Manchia, Mirko
Tortorella, Alfonso
Volpe, Umberto
Rosso, Gianluca
Carpiniello, Bernardo
Maina, Giuseppe
JOURNAL OF AFFECTIVE DISORDERS, 2015, 187 : 188 - 196
[6] An admixture analysis of the age at index episodes in bipolar disorder
Ortiz, Abigail
Bradler, Kamil
Slaney, Claire
Garnham, Julie
Ruzickova, Martina
O'Donovan, Claire
Hajek, Tomas
Alda, Martin
PSYCHIATRY RESEARCH, 2011, 188 (01) : 34 - 39
[7] Characterisation of age and polarity at onset in bipolar disorder
Kalman, Janos L.
Loohuis, Loes M. Olde
Vreeker, Annabel
McQuillin, Andrew
Stahl, Eli A.
Ruderfer, Douglas
Grigoroiu-Serbanescu, Maria
Panagiotaropoulou, Georgia
Ripke, Stephan
Bigdeli, Tim B.
Stein, Frederike
Meller, Tina
Meinert, Susanne
Pelin, Helena
Streit, Fabian
Papiol, Sergi
Adams, Mark J.
Adolfsson, Rolf
Adorjan, Kristina
Agartz, Ingrid
Aminoff, Sofie R.
Anderson-Schmidt, Heike
Andreassen, Ole A.
Ardau, Raffaella
Aubry, Jean-Michel
Balaban, Ceylan
Bass, Nicholas
Baune, Bernhard T.
Bellivier, Frank
Benabarre, Antoni
Bengesser, Susanne
Berrettini, Wade H.
Boks, Marco P.
Bromet, Evelyn J.
Brosch, Katharina
Budde, Monika
Byerley, William
Cervantes, Pablo
Chillotti, Catina
Cichon, Sven
Clark, Scott R.
Comes, Ashley L.
Corvin, Aiden
Coryell, William
Craddock, Nick
Craig, David W.
Croarkin, Paul E.
Cruceanu, Cristiana
Czerski, Piotr M.
Dalkner, Nina
BRITISH JOURNAL OF PSYCHIATRY, 2021, 219 (06) : 659 - 669
[8] Characteristics and profiles of bipolar I patients according to age-at-onset: Findings from an admixture analysis
Azorin, Jean-Michel
Bellivier, Frank
Kaladjian, Arthur
Adida, Marc
Belzeaux, Raoul
Fakra, Eric
Hantouche, Elie
Lancrenon, Sylvie
Golmard, Jean-Louis
JOURNAL OF AFFECTIVE DISORDERS, 2013, 150 (03) : 993 - 1000
[9] Admixture analysis of age of onset in generalized anxiety disorder
Rhebergen, Didi
Aderka, Idan M.
van der Steenstraten, Ira M.
van Balkom, Anton J. L. M.
van Oppen, Patricia
Stek, Max L.
Comijs, Hannie C.
Batelaan, Neeltje M.
JOURNAL OF ANXIETY DISORDERS, 2017, 50 : 47 - 51
[10] Bipolar disorder in the elderly; different effects of age and of age of onset
Oostervink, Frits
Boomsma, Maarten M.
Nolen, Willem A.
JOURNAL OF AFFECTIVE DISORDERS, 2009, 116 (03) : 176 - 183

← 1 2 3 4 5 →