Regulation of sphingosine kinase and sphingolipid signaling

被引:253
作者
Pitson, Stuart M. [1 ,2 ]
机构
[1] SA Pathol, Ctr Canc Biol, Adelaide, SA 5000, Australia
[2] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA 5005, Australia
基金
英国医学研究理事会;
关键词
PLASMA-MEMBRANE; DEPENDENT TRANSLOCATION; CELL-PROLIFERATION; DISTINCT ROLES; BINDING SITE; 1-PHOSPHATE; SPHINGOSINE-1-PHOSPHATE; ACTIVATION; PROTEIN; RELEASE;
D O I
10.1016/j.tibs.2010.08.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bioactive sphingolipids, including ceramide, sphingosine and sphingosine 1-phosphate are important regulators of many cellular processes, including cell survival, proliferation, differentiation, migration and immune responses. Although the levels of these bioactive sphingolipids are regulated by complex pathways subject to spatial and temporal control, the sphingosine kinases have emerged as critical central regulators of this system and, as a consequence, they have received substantial recent attention as potential therapeutic targets for cancer and a range of other conditions. Deciphering the molecular mechanisms that regulate both the activity and subcellular localization of these enzymes is vital for understanding the control of bioactive sphingolipid generation and action, and has clear implications for therapeutic strategies targeting these enzymes.
引用
收藏
页码:97 / 107
页数:11
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