Low serum IGF-I/GH ratio is associated with abnormal glucose tolerance in acromegaly

被引：10

作者：

Fukuoka, Hidenori ^{[1
]}

Takahashi, Yutaka ^{[1
]}

Iida, Keiji ^{[1
]}

Kudo, Takumi ^{[1
]}

Nishizawa, Hitoshi ^{[1
]}

Imanaka, Mari ^{[1
]}

Takeno, Ryoko ^{[1
]}

Iguchi, Genzo ^{[1
]}

Takahashi, Kentaro ^{[1
]}

Okimura, Yasuhiko ^{[2
]}

Kaji, Hidesuke ^{[3
]}

Chihara, Kazuo ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Clin Mol Med, Div Endocrinol Metab Nutr & Hematol Oncol,Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Kobe Univ, Sch Med, Dept Basic Allied Med, Kobe, Hyogo, Japan

[3] Univ Hyogo, Div Physiol Metabol, Kobe, Hyogo, Japan

来源：

HORMONE RESEARCH | 2008年 / 69卷 / 03期

关键词：

acromegaly; growth hormone; insulin-like growth factor-I; glucose tolerance; diabetes mellitus;

D O I：

10.1159/000112590

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/Aims: Acromegaly is frequently accompanied with impaired glucose tolerance (IGT) and diabetes mellitus ( DM). It remains unclear which factors determine the abnormal glucose tolerance status in acromegaly. In addition, diverse actions of GH and IGF-I in regulating glucose metabolism in acromegaly have not yet been well elucidated. The aim of this study was to investigate the factors associated with abnormal glucose tolerance in acromegaly. Subjects and Study Design: We conducted a retrospective cross-sectional study that included 48 patients with active acromegaly. The subjects were divided into two groups by the results of 75 g OGTT: normal glucose tolerance (NGT) group (n = 19) and IGT+ DM group (n = 29). Results: Systolic blood pressure (SBP) was significantly higher in the IGT+ DM than in the NGT group. Homeostasis model assessment of beta-cell function (HOMA-beta) was significantly decreased in the IGT+ DM group compared with the NGT group. Although serum GH or IGF-I levels were not different between the two groups, the IGF-I/GH ratio in the IGT+ DM group was significantly lower than that in the NGT group. Conclusions: We have shown that a low serum IGF-I/GH ratio was associated with abnormal glucose tolerance in acromegaly. We propose that the IGF-I/GH ratio is a useful marker to understand the metabolic status in acromegaly. Copyright (c) 2008 S. Karger AG, Basel.

引用

页码：165 / 171

页数：7

共 42 条

[21] β-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass [J].