Analytical Potentialities of Carbon Nanotube/Silicone Rubber Composite Electrodes: Determination of Propranolol

被引：28

作者：

dos Santos, Sidney Xavier ^{[1
,2
]}

Cavalheiro, Eder T. G. ^{[2
]}

Brett, Christopher M. A. ^{[1
]}

机构：

[1] Univ Coimbra, Dept Quim, Fac Ciencias & Tecnol, P-3004535 Coimbra, Portugal

[2] Univ Sao Paulo, Dept Quim & Fis Mol, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil

来源：

ELECTROANALYSIS | 2010年 / 22卷 / 23期

基金：

巴西圣保罗研究基金会;

关键词：

Carbon nanotubes; Silicone rubber; Composite electrodes; Propranolol; Nanotubes; SENSITIVE ELECTROCHEMICAL DETECTION; NANOTUBES; BEHAVIOR; PASTE; PURIFICATION; BLOCKERS;

D O I：

10.1002/elan.201000262

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new composite electrode based on multiwall carbon nanotubes (MWCNT) and silicone-rubber (SR) was developed and applied to the determination of propranolol in pharmaceutical formulations. The effect of using MWCNT/graphite mixtures in different proportions was also investigated. Cyclic voltammetry and electrochemical impedance spectroscopy were used for electrochemical characterization of different electrode compositions. Propranolol was determined using MWCNT/SR 70% (m/m) electrodes with linear dynamic ranges up to 7.0 mu molL(-1) by differential pulse and up to 5.4 mu molL(-1) by square wave voltammetry, with LODs of 0.12 and 0.078 mu molL(-1), respectively. Analysis of commercial samples agreed with that obtained by the official spectrophotometric method. The electrode is mechanically robust and presented reproducible results and a long useful life.

引用

页码：2776 / 2783

页数：8

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