Catalytic Asymmetric Aldol Equivalents in the Enantioselective Synthesis of the Apoptolidin C Aglycone

被引：10

作者：

Vargo, Thomas R. ^{[1
]}

Hale, James S. ^{[1
]}

Nelson, Scott G. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 46期

关键词：

aldol reaction; asymmetric synthesis; cycloadditions; homogeneous catalysis; natural products; INDUCTION; EFFICIENT; COMPLETION;

D O I：

10.1002/anie.201004925

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aldol replacement: Catalytic asymmetric ketenealdehyde cycloadditions provide surrogates for traditional aldol additions in an enantioselective synthesis of apoptolidinoneC, the aglycone of the potent apoptosis regulator apoptolidinC. Eight of apoptolidinone C's ten stereocenters derive directly from these catalytic acetate or propionate aldol equivalents. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8678 / 8681

页数：4

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