Immunity and vaccine development efforts against Trypanosoma cruzi

被引：47

作者：

Rios, Lizette E. ^{[1
]}

Carlos Vazquez-Chagoyan, Juan ^{[2
]}

Ortega Pacheco, Antonio ^{[3
]}

Paola Zago, M. ^{[4
]}

Garg, Nisha J. ^{[1
,5
]}

机构：

[1] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[2] Univ Autonoma Estado Mexico, Fac Med Vet & Zootecnia, Ctr Invest & Estudios Avanzados Salud Anim, Toluca, Mexico

[3] Univ Autonoma Yucatan, Fac Med Vet & Zootecnia, Dept Salud Anim & Med Prevent, Merida, Yucatan, Mexico

[4] Univ Nacl Salta, Inst Patol Expt, CONICET, Salta, Argentina

[5] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA

来源：

ACTA TROPICA | 2019年 / 200卷

基金：

美国国家卫生研究院;

关键词：

Chagas; Prophylactic; Therapeutic; Vaccine; Immunity; Adjuvants; COMPLEMENT REGULATORY PROTEIN; PARAFLAGELLAR ROD PROTEINS; THERAPEUTIC DNA VACCINE; CHRONIC CHAGAS-DISEASE; TERT-BUTYL-NITRONE; TRANS-SIALIDASE; GENETIC IMMUNIZATION; PROTECTIVE IMMUNITY; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION;

D O I：

10.1016/j.actatropica.2019.105168

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a critical lack of methods for prevention of infection or treatment of acute infection and chronic disease. Studies in experimental models have suggested that the protective immunity against T. cruzi infection requires the elicitation of Th1 cytokines, lytic antibodies and the concerted activities of macrophages, T helper cells, and cytotoxic T lymphocytes (CTLs). In this review, we summarize the research efforts in vaccine development to date and the challenges faced in achieving an efficient prophylactic or therapeutic vaccine against human CD.

引用

页数：11

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