Identification of bioactives from Astragalus chinensis L.f. and their antioxidant, anti-inflammatory and anti-proliferative effects

被引：24
作者：
Hu, Ting [1 ,2 ]
Liu, Qi-Mei [2 ]
He, Xiao-Wei [2 ]
Huang, Fei [3 ]
Zhang, Ming-Wei [3 ]
Jiang, Jian-Guo [2 ]
机构：
[1] Wuhan Inst Technol, Sch Chem Engn & Pharm, Wuhan 430205, Hubei, Peoples R China
[2] South China Univ Technol, Coll Food & Bioengn, Guangzhou 510640, Guangdong, Peoples R China
[3] Guangdong Acad Agr Sci, Sericultural & Agr Food Res Inst, Key Lab Funct Foods, Minist Agr,Guangdong Key Lab Agr Prod Proc, Guangzhou 510610, Guangdong, Peoples R China
来源：
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE | 2017年 / 54卷 / 13期
基金：
中国国家自然科学基金;
关键词：
Astragalus chinensis L.f; Antioxidant; Antitumor; Anti-inflammatory; Formononetin; Calycosin; PHENOLIC-COMPOUNDS; CANCER CELLS; IN-VITRO; FORMONONETIN; FLAVONOIDS; APOPTOSIS; DAUCOSTEROL; EXTRACTION; FRACTION; PATHWAY;
D O I：
10.1007/s13197-017-2902-3
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
This work was designed to obtain the valuable compounds with antioxidant, anti-proliferative and anti-inflammatory activities from Astragalus chinensis. Ethyl acetate fraction obtained from A. chinensis L.f. had significant antioxidant, anti-proliferative and anti-inflammatory activities. Subsequently, five single compounds were separated and purified, which were identified as formononetin (1), rhamnocitrin (2), calycosin (3), beta-daucosterol (4), rhamnocitrin-3-O-beta-d-glucoside (5). The results displayed that formononetin and rhamnocitrin exhibited significant cytotoxicity actions against tumor cell lines. Calycosin exerted the strongest anti-inflammatory effect of inhibition effects on NO production in macrophages.
引用
收藏
页码：4315 / 4323
页数：9
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