Fecal Microbiota Transplantation: Current Status in Treatment of GI and Liver Disease

被引：61
作者：
Vaughn, Byron P. [1 ]
Rank, Kevin M. [1 ]
Khoruts, Alexander [1 ,2 ,3 ]
机构：
[1] Univ Minnesota, Dept Med, Div Gastroenterol, Box 736 UMHC, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Ctr Immunol, Minneapolis, MN USA
[3] Univ Minnesota, Inst Biotechnol, Minneapolis, MN USA
来源：
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2019年 / 17卷 / 02期
关键词：
Fecal Microbiota Transplantation; Clostridium difficile Infection; Pathobiome; Inflammatory Bowel Disease; Irritable Bowel Syndrome; Liver Disease; CLOSTRIDIUM-DIFFICILE INFECTION; ACTIVE ULCERATIVE-COLITIS; INFLAMMATORY-BOWEL-DISEASE; INTESTINAL MICROBIOTA; INSULIN SENSITIVITY; GUT MICROBIOME; CASE-SERIES; DONOR; DIARRHEA; HOST;
D O I：
10.1016/j.cgh.2018.07.026
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Fecal microbiota transplantation was originally introduced as a method to repair intestinal microbiota following failure of multiple treatments of recurrent Clostridium difficile infection with antibiotics. However, it is hypothesized that intestinal dysbiosis may contribute to the pathogenesis of many diseases, especially those involving the gastrointestinal tract. Therefore, fecal microbiota transplantation is increasingly being explored as a potential treatment that aims to optimize microbiota composition and functionality. Here, we review the current state of fecal microbiota transplantation development and applications in conditions of greatest interest to a gastroenterologist.
引用
收藏
页码：353 / 361
页数：9
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