Doxycycline-induced acquired haemophilia A

被引:2
作者
Shah, Ejaz [1 ]
Abro, Calvin [2 ]
Zaidi, Fawwad [2 ]
Goel, Ruchika [2 ]
机构
[1] HSHS St Johns Hosp, Internal Med, Springfield, IL 62769 USA
[2] Southern Illinois Univ, Sch Med, Haematol & Oncol, Springfield, IL 62708 USA
关键词
haematology (incl blood transfusion); drugs and medicines; unwanted effects; adverse reactions; FACTOR-VIII INHIBITORS;
D O I
10.1136/bcr-2021-244748
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
An 80-year-old man with no personal or family history of bleeding, presented to hospital with extensive haematomas and skin bruising after using doxycycline. His basic lab workup was concerning for a coagulopathy with an elevated activated partial thromboplastin time and significant anaemia. Mixing studies and other factor levels were tested that led to the diagnosis of acquired haemophilia A with low factor VIII levels and high factor VIII antibodies. He was started on steroids, but his haemoglobin level continued to drop. Later, during his treatment, he was given multiple therapeutic agents, including cyclophosphamide, rituximab and recombinant factor VII (NovoSeven-R). Gradually factor VIII levels increased and haemoglobin stabilised. The hospital course was complicated by COVID-19 pneumonia leading to acute respiratory distress syndrome; the patient eventually expired due to respiratory failure.
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页数:3
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