Antiviral and Antioxidant Properties of Echinochrome A

被引：59

作者：

Fedoreyev, Sergey A. ^{[1
]}

Krylova, Natalia V. ^{[2
]}

Mishchenko, Natalia P. ^{[1
]}

Vasileva, Elena A. ^{[1
]}

Pislyagin, Evgeny A. ^{[1
]}

Iunikhina, Olga V. ^{[2
]}

Lavrov, Vyacheslav F. ^{[3
]}

Svitich, Oksana A. ^{[3
]}

Ebralidze, Linna K. ^{[3
]}

Leonova, Galina N. ^{[2
]}

机构：

[1] RAS, GB Elyakov Pacific Inst Bioorgan Chem, FEB, Vladivostok 690022, Russia

[2] RAS, GP Somov Inst Epidemiol & Microbiol, FEB, Vladivostok 690087, Russia

[3] II Mechnikov Res Inst Vaccines & Sera, Moscow 105064, Russia

来源：

MARINE DRUGS | 2018年 / 16卷 / 12期

关键词：

echinochrome A; composition of antioxidants; antioxidant activity; antiviral activity; OXIDATIVE STRESS; VITAMIN-E; FAR-EAST; INFECTION; MARINE;

D O I：

10.3390/md16120509

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1). The antioxidant composition, which is a mixture of echinochrome A, ascorbic acid, and -tocopherol (5:5:1), showed higher antioxidant and antiviral effects than echinochrome A. We suppose that echinochrome A and its composition can both directly affect virus particles and indirectly enhance antioxidant defense mechanisms in the hosting cell. The obtained results allow considering the echinochrome A and the composition of antioxidants on its basis as the promising agents with the both antioxidant and antiviral activities.

引用

页数：10

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