Antiviral and Antioxidant Properties of Echinochrome A

被引：59
作者：
Fedoreyev, Sergey A. [1 ]
Krylova, Natalia V. [2 ]
Mishchenko, Natalia P. [1 ]
Vasileva, Elena A. [1 ]
Pislyagin, Evgeny A. [1 ]
Iunikhina, Olga V. [2 ]
Lavrov, Vyacheslav F. [3 ]
Svitich, Oksana A. [3 ]
Ebralidze, Linna K. [3 ]
Leonova, Galina N. [2 ]
机构：
[1] RAS, GB Elyakov Pacific Inst Bioorgan Chem, FEB, Vladivostok 690022, Russia
[2] RAS, GP Somov Inst Epidemiol & Microbiol, FEB, Vladivostok 690087, Russia
[3] II Mechnikov Res Inst Vaccines & Sera, Moscow 105064, Russia
来源：
MARINE DRUGS | 2018年 / 16卷 / 12期
关键词：
echinochrome A; composition of antioxidants; antioxidant activity; antiviral activity; OXIDATIVE STRESS; VITAMIN-E; FAR-EAST; INFECTION; MARINE;
D O I：
10.3390/md16120509
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1). The antioxidant composition, which is a mixture of echinochrome A, ascorbic acid, and -tocopherol (5:5:1), showed higher antioxidant and antiviral effects than echinochrome A. We suppose that echinochrome A and its composition can both directly affect virus particles and indirectly enhance antioxidant defense mechanisms in the hosting cell. The obtained results allow considering the echinochrome A and the composition of antioxidants on its basis as the promising agents with the both antioxidant and antiviral activities.
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页数：10
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