Advances in Aptamers

被引：66
作者：
Syed, Muhammad Ali [1 ]
Pervaiz, Saima [2 ]
机构：
[1] Comsats Inst Informat Technol, Dept Biosci, Islamabad 44000, Pakistan
[2] Pir Mehr Ali Shah Arid Agr Univ, Dept Zool, Rawalpindi, Pakistan
来源：
OLIGONUCLEOTIDES | 2010年 / 20卷 / 05期
关键词：
FUNCTIONALIZED GOLD NANOPARTICLES; RNA APTAMER; PRION PROTEIN; DNA APTAMERS; CELL-SELEX; APTASENSORS; DISCOVERY; AFFINITY; DELIVERY; IDENTIFICATION;
D O I：
10.1089/oli.2010.0234
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aptamers are nucleic acid sequences synthesized through in vitro selection and amplification technique, possessing a broader range of applications in therapeutics, biosensing, diagnostics, and research. Aptamers offer a number of advantages over their antibodies counterpart, one of them is their ability to undergo chemical derivatization to increase their life in the body fluids and bioavailability in animals. Although aptamers were discovered in 1990s, they have become one of the most widely investigated molecules, with a huge number of publications in the last decade. This article presents an overview of the advancements that have been made in aptamers. We mainly focused on articles published since 2005.
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页码：215 / 224
页数：10
相关论文
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