Extension up to 50 MeV incident deuteron energy is presented for excitation functions of activation products formed in monoisotopic Tm (Tm-169) and Pr (Pr-141). By stacked foil irradiations direct and/or cumulative production of Nd-140,Nd-139m,Nd-138, Pr-138m, Ce-141,Ce-139.137m,Ce-135 on Pr and Yb-166,Yb-169, Tm-166,Tm-167,Tm-168 on Tm targets were measured. Confirmation of earlier experimental results for all investigated radionuclides is found and the influence of the higher energy on thick target yields and batch production of medically relevant radionuclides (Nd-140, Pr-139 (as decay product of Nd-139m), (166,169) Yb, Tm-167) is discussed. A comparison of experimental values with TALYS1.6 code results (predicted values from TENDL-2015 on-line library) shows a better description of the (d,pxn) reactions than older ones. (C) 2016 Elsevier B.V. All rights reserved.