Inhibition of Human Tumor Cell Proliferation by the Telomerase Inhibitor TELIN

被引：6

作者：

Kakiuchi, Yasutaka ^{[1
]}

Oyama, Mika ^{[1
]}

Nakatake, Mayuka ^{[1
]}

Okamoto, Yayoi ^{[1
]}

Kai, Hirofumi ^{[2
]}

Arima, Hidetoshi ^{[3
]}

Murofushi, Hiromu ^{[4
]}

Murakami-Murofushi, Kimiko ^{[1
]}

机构：

[1] Ochanomizu Univ, Fac Sci, Dept Biol, Bunkyo Ku, Tokyo 1128610, Japan

[2] Kumamoto Univ, Fac Pharmaceut Sci, Dept Mol Med, Kumamoto 8620973, Japan

[3] Kumamoto Univ, Fac Med & Pharmaceut Sci, Dept Phys Pharmaceut, Kumamoto 8620973, Japan

[4] Yamaguchi Univ, Fac Sci, Dept Phys Biol & Informat, Yamaguchi 7538511, Japan

来源：

CYTOLOGIA | 2010年 / 75卷 / 02期

关键词：

Telomere; Telomerase; Anticancer drug; Delivery efficiency; HTERT;

D O I：

10.1508/cytologia.75.177

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

TELIN, a newly developed catalytic blocker of telomerase, was assessed for its antiproliferative activity against human tumor cells in in vitro cell culture assay. TELIN suppressed cell proliferations of several blood tumor cells with telomere shortening and the appearance of apoptotic small cells, but did not affect hTERT mRNA expression, suggesting that TELIN catalytically inhibited telomerase activity within the cells. TELIN also suppressed cell proliferation of adherent tumor cells, whereas it did not affect the growth of normal fibroblasts. Delivery efficiency of TELIN was significantly different between several delivery carriers, and beta-cyclodextrin was found to be a suitable carrier.

引用

页码：177 / 183

页数：7

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