Functional characterization of chicken cytokines homologous to mammalian IL-15 and IL-2

被引：0
|
作者：
Lillehoj, HS [1 ]
Min, WG [1 ]
Choi, KD [1 ]
Babu, US [1 ]
Burnside, J [1 ]
Miyamoto, T [1 ]
Lillehoj, EP [1 ]
机构：
[1] USDA ARS, Beltsville Agr Res Ctr, Livestock & Poultry Sci Inst, Beltsville, MD 20705 USA
来源：
CURRENT PROGRESS ON AVIAN IMMUNOLOGY RESEARCH, PROCEEDINGS | 2001年
关键词：
chickens; cytokines; interleukin-2; interleukin-15; NK cells;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Full-length cDNA encoding chicken IL-15 was cloned from chicken liver cDNA library and its functional characteristics were compared to chicken IL-2. Both recombinant IL-2 and IL-15 stimulated the growth of T cells and enhanced the activity NK-cells in vitro. Subcutaneous injection of chickens with IL-2 genes increased the percentages of CD3+, CD4+, CD8+, gammadelta T, and alphabeta T lymphocytes. In contrast, injection of chickens with IL-15 gene preferentially enhanced CD3+ T lymphocytes. Collectively, these results indicate that chicken IL-15 and IL-2 represent T cell growth factors and these cytokines enhance host immunity mediated by T and NK cells.
引用
收藏
页码：8 / 13
页数：6
相关论文
共 50 条
  • [41] Electrotransfer of IL-15/IL-15Rα Complex for the Treatment of Established Melanoma
    Shirley, Shawna A.
    Lundberg, Cathryn G.
    Heller, Richard
    CANCERS, 2020, 12 (10) : 1 - 15
  • [42] Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients
    Santos Savio, Alicia
    Machado Diaz, Ana Cecilia
    Chico Capote, Araceli
    Miranda Navarro, Jamilet
    Rodriguez Alvarez, Yunier
    Bringas Perez, Ricardo
    Estevez del Toro, Miguel
    Guillen Nieto, Gerardo E.
    BMC MUSCULOSKELETAL DISORDERS, 2015, 16
  • [43] Immunotherapeutic applications of IL-15
    Croce, Michela
    Orengo, Anna Maria
    Azzarone, Bruno
    Ferrini, Silvano
    IMMUNOTHERAPY, 2012, 4 (09) : 957 - 969
  • [44] Effect of interleukins (IL-2, IL-15, IL-18) on receptors activation and cytotoxic activity of natural killer cells in breast cancer cell
    Widowati, Wahyu
    Jasaputra, Diana K.
    Sumitro, Sutiman B.
    Widodo, Mochammad A.
    Mozef, Tjandrawati
    Rizal, Rizal
    Kusuma, Hanna Sari W.
    Laksmitawati, Dian R.
    Murti, Harry
    Bachtiar, Indra
    Faried, Ahmad
    AFRICAN HEALTH SCIENCES, 2020, 20 (02) : 822 - 832
  • [45] Generation of high-affinity CMV-specific T cells for adoptive immunotherapy using IL-2, IL-15, and IL-21
    Luo, Xiao-Hua
    Meng, Qingda
    Liu, Zhenjiang
    Paraschoudi, Georgia
    CLINICAL IMMUNOLOGY, 2020, 217
  • [46] Global transcriptome-wide analysis of CIK cells identify distinct roles of IL-2 and IL-15 in acquisition of cytotoxic capacity against tumor
    Wenju Wang
    Mingyao Meng
    Yayong Zhang
    Chuanyu Wei
    Yanhua Xie
    Lihong Jiang
    Chunhui Wang
    Fang Yang
    Weiwei Tang
    Xingfang Jin
    Dai Chen
    Jie Zong
    Zongliu Hou
    Ruhong Li
    BMC Medical Genomics, 7
  • [47] IL-15 and IL-2 increase Cetuximab-mediated cellular cytotoxicity against triple negative breast cancer cell lines expressing EGFR
    Roberti, M. P.
    Barrio, M. M.
    Bravo, A. I.
    Rocca, Y. S.
    Arriaga, J. M.
    Bianchini, M.
    Mordoh, J.
    Levy, E. M.
    BREAST CANCER RESEARCH AND TREATMENT, 2011, 130 (02) : 465 - 475
  • [48] IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes
    Apert, Cecile
    Galindo-Albarran, Ariel O.
    Castan, Sarah
    Detraves, Claire
    Michaud, Heloise
    McJannett, Nicola
    Haegeman, Bart
    Fillatreau, Simon
    Malissen, Bernard
    Hollander, Georg
    Zuklys, Saulius
    Santamaria, Jeremy C.
    Joffre, Olivier P.
    Romagnoli, Paola
    van Meerwijk, Joost P. M.
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [49] The CIK cells stimulated with combination of IL-2 and IL-15 provide an improved cytotoxic capacity against human lung adenocarcinoma
    Wei, Chuanyu
    Wang, Wenju
    Pang, Wei
    Meng, Mingyao
    Jiang, Lihong
    Xue, Sha
    Xie, Yanhua
    Li, Ruhong
    Hou, Zongliu
    TUMOR BIOLOGY, 2014, 35 (03) : 1997 - 2007
  • [50] Phospho-proteomics reveals that RSK signaling is required for proliferation of natural killer cells stimulated with IL-2 or IL-15
    MacMullan, Melanie A.
    Wang, Pin
    Graham, Nicholas A.
    CYTOKINE, 2022, 157
12345